Search International and National Patent Collections

1. (WO2018143736) HYDROGEL USING, AS SUBSTRATE, HYALURONIC ACID DERIVATIVE MODIFIED WITH GALLOL GROUP AND USE THEREOF

Pub. No.:    WO/2018/143736    International Application No.:    PCT/KR2018/001473
Publication Date: Fri Aug 10 01:59:59 CEST 2018 International Filing Date: Sat Feb 03 00:59:59 CET 2018
IPC: C08B 37/08
C08J 3/075
C08L 5/08
A61L 27/20
A61L 27/54
A61K 47/36
Applicants: AMTIXBIO CO., LTD.
(주)앰틱스바이오
Inventors: CHO, Seung Woo
조승우
LEE, Jung-Seung
이정승
CHO, Jung Ho
조정호
LEE, Jong-Seung
이종승
Title: HYDROGEL USING, AS SUBSTRATE, HYALURONIC ACID DERIVATIVE MODIFIED WITH GALLOL GROUP AND USE THEREOF
Abstract:
The present invention provides a hydrogel platform using, as a substrate, hyaluronic acid (HA) conjugated to a pyrogallol (PG) moiety. The HA-PG conjugate of the present invention can be promptly crosslinked by two different methods, such as using an oxidant or adjusting pH. The hydrogel of the present invention can efficiently control physical characteristics, such as a crosslinking rate, elasticity, and adhesive strength, according to the crosslinking manner of each, while having excellent biocompatibility. The hydrogel of the present invention can be used, on the basis of such excellent stability and functionality thereof, in various fields including drug delivery, biopharmaceutical materials such as a wound healing agent or anti-adhesive agent, medicines, and cosmetic products.