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1. (WO2018143615) PHARMACEUTICAL COMPOSITION CONTAINING PEROXIREDOXIN 1 PROTEIN ACTIVITY INHIBITOR AS ACTIVE INGREDIENT FOR PREVENTING OR TREATING BONE DISEASE

Pub. No.:    WO/2018/143615    International Application No.:    PCT/KR2018/001189
Publication Date: Fri Aug 10 01:59:59 CEST 2018 International Filing Date: Sat Jan 27 00:59:59 CET 2018
IPC: A61K 39/395
A23L 33/10
G01N 33/50
G01N 33/68
Applicants: SOOKMYUNG WOMEN'S UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
숙명여자대학교 산학협력단
Inventors: YIM, Mijung
임미정
KANG, Ju-Hee
강주희
Title: PHARMACEUTICAL COMPOSITION CONTAINING PEROXIREDOXIN 1 PROTEIN ACTIVITY INHIBITOR AS ACTIVE INGREDIENT FOR PREVENTING OR TREATING BONE DISEASE
Abstract:
The present invention relates to a pharmaceutical composition containing a peroxiredoxin 1 protein activity inhibitor as an active ingredient for preventing or treating a bone disease. Specifically, the peroxiredoxin 1 protein of the present invention induces the differentiation of preosteoclasts, and an antibody against the peroxiredoxin 1 protein inhibits the increase of osteoclasts induced by lipopolysaccharides and the bone loss in a bone loss animal model, so that the peroxiredoxin 1 protein activity inhibitor can be advantageously utilized in the prevention or treatment of a bone disease.