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1. (WO2018143406) IMAGE PROCESSING DEVICE AND PROGRAM
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Pub. No.: WO/2018/143406 International Application No.: PCT/JP2018/003587
Publication Date: 09.08.2018 International Filing Date: 02.02.2018
IPC:
G01N 33/48 (2006.01) ,G01N 21/64 (2006.01) ,G01N 33/483 (2006.01)
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21
Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible, or ultra-violet light
62
Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
63
optically excited
64
Fluorescence; Phosphorescence
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
483
Physical analysis of biological material
Applicants:
コニカミノルタ株式会社 KONICA MINOLTA, INC. [JP/JP]; 東京都千代田区丸の内二丁目7番2号 2-7-2, Marunouchi, Chiyoda-ku, Tokyo 1007015, JP
Inventors:
吉原 由佳 YOSHIHARA, Yuka; JP
Agent:
特許業務法人光陽国際特許事務所 KOYO INTERNATIONAL PATENT FIRM; 東京都千代田区有楽町一丁目1番3号 東京宝塚ビル17階 17F., Tokyo Takarazuka Bldg., 1-1-3, Yurakucho, Chiyoda-ku, Tokyo 1000006, JP
Priority Data:
2017-01939506.02.2017JP
Title (EN) IMAGE PROCESSING DEVICE AND PROGRAM
(FR) DISPOSITIF ET PROGRAMME DE TRAITEMENT D'IMAGES
(JA) 画像処理装置及びプログラム
Abstract:
(EN) The present invention addresses the problem of providing an image processing device and a program whereby an expression pattern of a biological substance in a tissue specimen can be quantitatively evaluated, and the expression level of the biological substance for each cell can easily be recognized visually. The present invention is provided with an input means for inputting a form image representing the form of a cell and a fluorescence image in the same range as the form image and in which expression of the biological substance is represented by fluorescent bright points in a tissue specimen in which one or a plurality of types of biological substances are stained, a first extraction means for extracting a cell region from the form image, a second extraction means for extracting a fluorescent bright point region from the fluorescence image, a generating means for calculating the expression level of the biological substance from the number of fluorescent bright point regions extracted by the second extraction means and generating expression pattern information 233 including the expression level, and a classifying means for separating cells into classes in accordance with the expression pattern information generated by the generating means.
(FR) La présente invention aborde le problème de réalisation d'un dispositif de traitement d'images et d'un programme selon lesquels un motif d'expression d'une substance biologique dans un spécimen de tissu peut être évalué quantitativement, et le niveau d'expression de la substance biologique pour chaque cellule peut facilement être reconnu visuellement. La présente invention comporte un moyen d'entrée destiné à entrer une image de forme représentant la forme d'une cellule et une image de fluorescence dans la même plage que l'image de forme dans laquelle l'expression de la substance biologique est représentée par des points lumineux fluorescents dans un spécimen de tissu dans lequel un type ou une pluralité de types de substances biologiques sont teints, un premier moyen d'extraction destiné à extraire une zone de cellule de l'image de forme, un deuxième moyen d'extraction destiné à extraire une zone de points lumineux fluorescents de l'image fluorescente, un moyen générateur destiné à calculer le niveau d'expression de la substance biologique à partir du nombre de zones de points lumineux fluorescents extraits par le deuxième moyen d'extraction et à générer des informations de motif d'expression (233) incluant le niveau d'expression, et un moyen de classification destiné à séparer des cellules en classes en fonction des informations de motif d'expression générées par le moyen générateur.
(JA) 本発明の課題は、組織標本における生体物質の発現パターンを定量的に評価可能であって、細胞ごとの生体物質の発現量を容易に視認可能な画像処理装置及びプログラムを提供することである。単一又は複数種類の生体物質が染色された組織標本における、細胞の形態を表す形態画像及び形態画像と同一範囲の生体物質の発現を蛍光輝点で表す蛍光画像を入力する入力手段と、形態画像から細胞領域を抽出する第1抽出手段と、蛍光画像から蛍光輝点領域を抽出する第2抽出手段と、第2抽出手段によって抽出された、蛍光輝点領域の数から生体物質の発現量を算出し、当該発現量を含む発現パターン情報233を生成する生成手段と、生成手段によって生成された、発現パターン情報に応じて細胞のクラス分けを行う分類手段と、を備える。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)