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1. (WO2018143162) COMPOUND SERVING AS PRODRUG OF HYDROXAMIC ACID OR SALT OF SAID COMPOUND, FREEZE-DRIED MEDICINAL PREPARATION, LpxC INHIBITOR, AND ANTIBACTERIAL
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Pub. No.: WO/2018/143162 International Application No.: PCT/JP2018/002874
Publication Date: 09.08.2018 International Filing Date: 30.01.2018
IPC:
C07F 9/09 (2006.01) ,A61K 9/19 (2006.01) ,A61K 31/661 (2006.01) ,A61P 31/04 (2006.01) ,A61P 43/00 (2006.01) ,C12N 9/18 (2006.01)
Applicants: TOYAMA CHEMICAL CO., LTD.[JP/JP]; 2-5, Nishishinjuku 3-chome, Shinjuku-ku, Tokyo 1600023, JP
Inventors: SHOJI Muneo; JP
NAGATO Yusuke; JP
SUZUMURA Yuko; JP
Agent: SIKS & CO.; 8th Floor, Kyobashi-Nisshoku Bldg., 8-7, Kyobashi 1-chome, Chuo-ku, Tokyo 1040031, JP
Priority Data:
2017-01510831.01.2017JP
Title (EN) COMPOUND SERVING AS PRODRUG OF HYDROXAMIC ACID OR SALT OF SAID COMPOUND, FREEZE-DRIED MEDICINAL PREPARATION, LpxC INHIBITOR, AND ANTIBACTERIAL
(FR) COMPOSÉ SERVANT DE PROMÉDICAMENT D'ACIDE HYDROXAMIQUE OU DE SEL DUDIT COMPOSÉ, PRÉPARATION MÉDICINALE LYOPHILISÉE, INHIBITEUR DE LpxC ET ANTIBACTÉRIEN
(JA) ヒドロキサム酸のプロドラッグである化合物またはその塩、凍結乾燥製剤、LpxC阻害剤および抗菌剤
Abstract: front page image
(EN) The present invention addresses the problem of providing: a compound which shows potent antibacterial activity and excellent solubility in water or a salt of the compound; and a freeze-dried medicinal preparation, an LpxC inhibitor, and an antibacterial each containing the compound or salt. According to the present invention, a compound represented by general formula [1] or a salt thereof is provided. [In formula [1], R1 represents a hydrogen atom, etc.; R2 represents a hydrogen atom, etc.; R3 represents a hydrogen atom, etc.; R4 represents a hydrogen atom, etc.; and n is 0 or 1.]
(FR) La présente invention aborde le problème consistant à fournir : un composé qui présente une activité antibactérienne puissante et une excellente solubilité dans l'eau ou un sel du composé; et une préparation médicinale lyophilisée, un inhibiteur de LpxC et un antibactérien contenant chacun le composé ou le sel. La présente invention concerne un composé représenté par la formule général [1] ou un sel de celui-ci. [Dans la formule [1], R1 représente un atome d'hydrogène, etc.; R2 représente un atome d'hydrogène, etc.; R3 représente un atome d'hydrogène, etc.; R4 représente un atome d'hydrogène, etc.; n vaut 0 ou 1.]
(JA) 本発明の課題は、強い抗菌活性を示し、水に対して溶解性が優れた化合物またはその塩、並びに上記の化合物またはその塩を含有する、凍結乾燥製剤、LpxC阻害剤、および抗菌剤を 提供することである。本発明によれば、一般式[1] 「式中、Rは、水素原子などを、Rは、水素原子などを、Rは、水素原子などを、Rは、水素原子などを、nは、0または1を表す。」で表される化合物またはその塩が提供される。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)