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1. (WO2018142416) ISOLATED CELLS GENETICALLY MODIFIED TO EXPRESS A DISARM SYSTEM HAVING AN ANTI-PHAGE ACTIVITY AND METHODS OF PRODUCING SAME
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Pub. No.: WO/2018/142416 International Application No.: PCT/IL2018/050134
Publication Date: 09.08.2018 International Filing Date: 06.02.2018
IPC:
C07K 14/195 (2006.01) ,C12N 9/10 (2006.01) ,C12N 1/20 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
195
from bacteria
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9
Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
10
Transferases (2.)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
1
Micro-organisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving micro-organisms or compositions thereof; Processes of preparing or isolating a composition containing a micro-organism; Culture media therefor
20
Bacteria; Culture media therefor
Applicants:
YEDA RESEARCH AND DEVELOPMENT CO. LTD. [IL/IL]; at the Weizmann Institute of Science P.O. Box 95 7610002 Rehovot, IL
Inventors:
SOREK, Rotem; IL
SBERRO, Hila; IL
OFIR, Gal; IL
MELAMED, Sarah; IL
Agent:
COHEN, Mark, S.; IL
Priority Data:
25047906.02.2017IL
Title (EN) ISOLATED CELLS GENETICALLY MODIFIED TO EXPRESS A DISARM SYSTEM HAVING AN ANTI-PHAGE ACTIVITY AND METHODS OF PRODUCING SAME
(FR) CELLULES ISOLÉES GÉNÉTIQUEMENT MODIFIÉES POUR EXPRIMER UN SYSTÈME DISARM AYANT UNE ACTIVITÉ ANTI-PHAGE ET LEURS PROCÉDÉS DE PRODUCTION
Abstract:
(EN) Isolated cells genetically modified to express a DISRAM system are provided. Accordingly there is provided an isolated cell genetically modified to express a DISARM system having an anti-phage activity, the system comprising a drmM polypeptide; a drmA polypeptide; a drmB polypeptide; and a drmD polypeptide or a drmE polypeptide. Also provided are compositions and methods for conferring phage resistance to bacteria or for conferring bacterial susceptibility to phages.
(FR) L'invention concerne des cellules isolées génétiquement modifiées pour exprimer un système DISRAM. L'invention concerne également une cellule isolée génétiquement modifiée pour exprimer un système DISARM ayant une activité anti-phage, le système comprenant un polypeptide drmM ; un polypeptide drmA ; un polypeptide drmB ; et un polypeptide drmD ou un polypeptide drmE. L'invention concerne en outre, des compositions et des procédés pour conférer une résistance aux phages à des bactéries ou pour conférer une sensibilité bactérienne aux phages.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Licensing availability request The applicant has requested the International Bureau to indicate the availability for licensing purposes of the invention(s) claimed in this international application