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1. (WO2018142109) PROCESS OF PRODUCING MONOTERPENES

Pub. No.:    WO/2018/142109    International Application No.:    PCT/GB2018/050223
Publication Date: Fri Aug 10 01:59:59 CEST 2018 International Filing Date: Sat Jan 27 00:59:59 CET 2018
IPC: C12P 5/00
C12P 5/02
C12P 7/04
C12P 17/06
C12P 17/02
Applicants: THE UNIVERSITY OF MANCHESTER
Inventors: KARUPPIAH, Vijaykumar
G. H. LEFERINK, Nicole
S. SCRUTTON, Nigel
Title: PROCESS OF PRODUCING MONOTERPENES
Abstract:
The present invention relates to a process of producing a monoterpene and/or derivatives thereof. The process comprises the steps of: a) providing a host microorganism genetically engineered to express a bacterial monoterpene synthase (mTS); and b) contacting geranyl pyrophosphate (GPP) with said bacterial mTS to produce said monoterpene and/or derivatives thereof. The present invention also relates to a microorganism for use in producing a monoterpene and/ or derivatives thereof and a recombinant microorganism adapted to conduct the step of converting geranyl pyrophosphate (GPP) into a monoterpene and/or derivatives thereof by expression of a bacterial mTS. It was shown to produce 1,8 cineole using 1,8 cineole synthase and to produce linalool using linalool synthase, both from Streptomyces clavuligerus.