Some content of this application is unavailable at the moment.
If this situation persists, please contact us atFeedback&Contact
1. (WO2018141959) IMMUNOMODULATORY ANTIBODY DRUG CONJUGATES BINDING TO A HUMAN MICA POLYPEPTIDE
Latest bibliographic data on file with the International BureauSubmit observation

Pub. No.: WO/2018/141959 International Application No.: PCT/EP2018/052801
Publication Date: 09.08.2018 International Filing Date: 05.02.2018
IPC:
C07K 16/28 (2006.01) ,A61K 47/68 (2017.01) ,A61P 35/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
28
against receptors, cell surface antigens or cell surface determinants
[IPC code unknown for A61K 47/68]
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants:
INNATE PHARMA [FR/FR]; 117 Avenue de Luminy 13009 Marseille, FR
Inventors:
BLERY, Mathieu; FR
BREGEON, Delphine; FR
GAUTHIER, Laurent; FR
LHOSPICE, Florence; FR
POUYET, Laurent; FR
Agent:
VOLLMY, Lukas; FR
Priority Data:
62/455,01906.02.2017US
Title (EN) IMMUNOMODULATORY ANTIBODY DRUG CONJUGATES BINDING TO A HUMAN MICA POLYPEPTIDE
(FR) CONJUGUÉS MÉDICAMENT ANTICORPS IMMUNOMODULATEURS SE LIANT À UN POLYPEPTIDE MICA HUMAIN
Abstract:
(EN) The present invention provides antigen-binding proteins capable of binding to human MICA polypeptides, conjugated to cytotoxic agents. Said conjugates have increased activity in the treatment of disorders characterized by MICA-expressing cells, particularly tumor cells.
(FR) La présente invention concerne des protéines de liaison à un antigène pouvant se lier aux polypeptides MICA humains, conjugués à des agents cytotoxiques. Les conjugués de la présente invention présentent une activité accrue dans le traitement de troubles caractérisés par des cellules exprimant des MICA, en particulier des cellules tumorales.
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)