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1. (WO2018141910) LOW PH PHARMACEUTICAL COMPOSITION COMPRISING T CELL ENGAGING ANTIBODY CONSTRUCTS

Pub. No.:    WO/2018/141910    International Application No.:    PCT/EP2018/052665
Publication Date: Fri Aug 10 01:59:59 CEST 2018 International Filing Date: Sat Feb 03 00:59:59 CET 2018
IPC: A61K 39/395
C07K 16/28
Applicants: AMGEN RESEARCH (MUNICH) GMBH
AMGEN INC.
Inventors: MCAULEY, Arnold
GHATTYVENKATAKRISHNA, Pavan
ABEL, Jeff
HUH, Joon
POMPE, Cornelius
KANAPURAM, Sekhar
TREUHEIT, Michael
JAGANNATHAN, Bharadwaj
Title: LOW PH PHARMACEUTICAL COMPOSITION COMPRISING T CELL ENGAGING ANTIBODY CONSTRUCTS
Abstract:
The present disclosure provides a low pH pharmaceutical composition comprising (a) an antibody constructs comprising a first domain binding to a target cell surface antigen, a second domain binding to a second antigen and preferably a third domain, which is a specific Fc modality, (b) at least one buffer agent, (c) at least one saccharide, and (d) at least one surfactant; and wherein the pH of the pharmaceutical composition is in the range of 3.5 to 6.