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1. (WO2018141541) COMPOUND FOR IN VIVO DIAGNOSIS OF A DYSFUNCTION OF ADRENAL GLANDS

Pub. No.:    WO/2018/141541    International Application No.:    PCT/EP2018/050954
Publication Date: Fri Aug 10 01:59:59 CEST 2018 International Filing Date: Wed Jan 17 00:59:59 CET 2018
IPC: C07D 213/73
A61K 51/04
C07D 213/74
C07D 213/82
C07D 213/84
C07D 217/14
C07D 405/04
C07D 241/12
C07D 241/16
C07D 241/18
C07D 241/20
C07D 241/24
C07D 213/57
C07D 213/61
C07D 213/65
C07D 213/70
A61K 31/44
A61K 31/47
A61K 31/4965
Applicants: JULIUS-MAXIMILIANS-UNIVERSITÄT WÜRZBURG
Inventors: SCHIRBEL, Andreas
HEINZE, Britta
HAHNER, Stefanie
Title: COMPOUND FOR IN VIVO DIAGNOSIS OF A DYSFUNCTION OF ADRENAL GLANDS
Abstract:
The invention concerns a compound having formula (I): wherein R1 represents a radioactive isotope of an element which radioactive isotope is detectable by positron emission tomography (PET) or wherein R1 represents any nonradioactive isotope of said element, R2 represents –CN or –CF3, wherein R3 represents or, wherein * represents C or N and R4 represents one of the moieties of a group consisting of alkyl, alkyl ether, alkyl nitrile, alkyl alcohol, alkyl halide, O-alkyl, S- alkyl, halogen, nitrile, trifluoromethyl, amide, carbonyl pyrrolidine, pyrrolidinyl, 1 amino, aminoalkyl, aminodialkyl, phenyl, substituted phenyl, heterocyclic aromatic, substituted heterocyclic aromatic, saturated heterocyclic, substituted saturated heterocyclic, dioxolanyl, methyldioxolanyl, and dioxanyl.