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1. (WO2018141276) CRYSTAL FORM A OF BRIVARACETAM INTERMEDIATE AND PREPARATION METHOD THEREOF, AND CRYSTAL FORM C OF BRIVARACETAM AND PREPARATION METHOD THEREOF

Pub. No.:    WO/2018/141276    International Application No.:    PCT/CN2018/075177
Publication Date: Fri Aug 10 01:59:59 CEST 2018 International Filing Date: Sun Feb 04 00:59:59 CET 2018
IPC: C07D 207/27
C07C 231/24
C07C 233/47
A61K 31/4015
A61P 9/10
Applicants: SUZHOU PENGXU PHARMACEUTICAL TECHNOLOGY CO., LTD
苏州鹏旭医药科技有限公司
Inventors: LI, Pixu
李丕旭
WANG, Peng
王鹏
WEI, Qiang
魏强
Title: CRYSTAL FORM A OF BRIVARACETAM INTERMEDIATE AND PREPARATION METHOD THEREOF, AND CRYSTAL FORM C OF BRIVARACETAM AND PREPARATION METHOD THEREOF
Abstract:
Disclosed are a novel crystal form of a brivaracetam intermediate compound (I) and preparation method thereof, and a novel crystal form of brivaracetam and preparation method thereof, specifically a crystal form A of a compound I and a crystal form C of brivaracetam. The crystal form A provided in the present invention has beneficial properties such as good stability, technologically developable property, and easy-to-treat property; moreover, the crystal form A features a simple preparation method and low costs, and is significantly valuable for the production, the purification, and the quality control of active ingredients of the drug. The crystal form C provided in the present invention has beneficial properties such as good stability, technologically developable property, and easy-to-treat property; moreover, the crystal form A features a simple preparation method and low costs, and is significantly valuable for future optimization and development of the drug.