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1. (WO2018141263) PENICILONES DERIVATIVE AND APPLICATION THEREOF AS ANTI-RESISTANT BACTERIA DRUG
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/141263 International Application No.: PCT/CN2018/075069
Publication Date: 09.08.2018 International Filing Date: 02.02.2018
IPC:
C07D 311/76 (2006.01) ,A61K 31/352 (2006.01) ,A61P 31/04 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
311
Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
02
ortho- or peri-condensed with carbocyclic rings or ring systems
76
Benzo [c] pyrans
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
335
having oxygen as the only ring hetero atom, e.g. fungichromin
35
having six-membered rings with one oxygen as the only ring hetero atom
352
condensed with carbocyclic rings, e.g. cannabinols, methantheline
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
04
Antibacterial agents
Applicants: YANGZHOU BLUE BIOMEDICAL TECHNOLOGY COMPANY LIMITED[CN/CN]; Room 301, Yangzhou University Science Park No.131 Jiangyang Road Yangzhou, Jiangsu 225009, CN
Inventors: CHEN, Min; CN
Priority Data:
201710065001.804.02.2017CN
Title (EN) PENICILONES DERIVATIVE AND APPLICATION THEREOF AS ANTI-RESISTANT BACTERIA DRUG
(FR) DÉRIVÉ DE PÉNICILONES ET SON APPLICATION EN TANT QUE MÉDICAMENT ANTI-BACTÉRIES RÉSISTANTES
(ZH) PENICILONES衍生物及其作为抗耐药菌药物的应用
Abstract:
(EN) A penicilones derivative and an application thereof as an anti-resistant bacteria drug, in particular relating to a compound of formula I, stereoisomers thereof, tautomers thereof, solvates thereof, prodrugs thereof, and pharmaceutically acceptable salts thereof or solvates of the salts thereof, characterized in that the compound of formula I has the following structure: formula I. The compound shows strong antibacterial activity against methicillin-resistant Staphylococcus aureus, and the antibacterial activity thereof is superior to that of oxacillin sodium and comparable to that of vancomycin hydrochloride.
(FR) L'invention concerne un dérivé de pénicilones et une application de celui-ci en tant que médicament contre les bactéries résistantes. La présente invention concerne particulièrement, un composé de formule I, des stéréoisomères, des tautomères, des solvates, des promédicaments, et des sels pharmaceutiquement acceptables de celui-ci, ou des solvates de leurs sels, ayant la caractéristique en ce que le composé de formule I possède la structure suivante : formule I. Le composé de l'invention présente une forte activité antibactérienne contre Staphylococcus aureus résistant à la méthicilline, et son activité antibactérienne est supérieure à celle de l'oxacilline sodique et comparable à celle du chlorhydrate de vancomycine.
(ZH) 一种penicilones衍生物及其作为抗耐药菌药物的应用,具体涉及一种式I化合物、其立体异构体、其互变异构体、其溶剂化物、其前药、其药学上可接受的盐或其盐的溶剂化物,其特征在于式I化合物具有如下结构:式I,其对耐甲氧西林的金黄色葡萄球菌显示出很强的抗菌活性,优于苯唑西林钠的抗菌活性,与万古霉素盐酸盐的抗菌活性相当。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)