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1. (WO2018141089) HIV INHIBITING BROAD-SPECTRUM LIPOPEPTIDE, DERIVATIVES THEREOF, PHARMACEUTICAL COMPOSITIONS THEREOF, AND USE THEREOF
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Pub. No.: WO/2018/141089 International Application No.: PCT/CN2017/072885
Publication Date: 09.08.2018 International Filing Date: 04.02.2017
IPC:
C07K 14/155 (2006.01) ,A61K 39/21 (2006.01) ,A61K 47/10 (2006.01) ,A61P 31/18 (2006.01) ,A61P 31/14 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005
from viruses
08
RNA viruses
15
Retroviridae, e.g. bovine leukaemia virus, feline leukaemia virus, human T-cell leukaemia-lymphoma virus
155
Lentiviridae, e.g. human immunodeficiency virus (HIV), visna-maedi virus, equine infectious anaemia virus
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
12
Viral antigens
21
Retroviridae, e.g. equine infectious anemia virus
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
06
Organic compounds
08
containing oxygen
10
Alcohols; Phenols; Salts thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12
Antivirals
14
for RNA viruses
18
for HIV
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12
Antivirals
14
for RNA viruses
Applicants:
中国医学科学院病原生物学研究所 INSTITUTE OF PATHOGEN BIOLOGY, CHINESE ACADEMY OF MEDICAL SCIENCES [CN/CN]; 中国北京市 东城区东单三条9号 9 Dong Dan San Tiao Dong Cheng District Beijing 100730, CN
Inventors:
何玉先 HE, Yuxian; CN
种辉辉 CHONG, Huihui; CN
丁晓慧 DING, Xiaohui; CN
熊胜文 XIONG, Shengwen; CN
朱园美 ZHU, Yuanmei; CN
Agent:
北京纪凯知识产权代理有限公司 JEEKAI & PARTNERS; 中国北京市 丰台区广安路9号5号楼15A层 Floor 15A, Building No. 5 9 Guang'an Road, Fengtai District Beijing 100055, CN
Priority Data:
Title (EN) HIV INHIBITING BROAD-SPECTRUM LIPOPEPTIDE, DERIVATIVES THEREOF, PHARMACEUTICAL COMPOSITIONS THEREOF, AND USE THEREOF
(FR) LIPOPEPTIDE À LARGE SPECTRE D'INHIBITION DU VIH, DÉRIVÉS DE CELUI-CI, COMPOSITIONS PHARMACEUTIQUES ET UTILISATION ASSOCIÉES
(ZH) 广谱抑制HIV的脂肽、其衍生物、其药物组合物及其用途
Abstract:
(EN) Provided is a lipopeptide capable of inhibiting HIV. The lipopeptide comprises a polypeptide having antiviral activity, a connecting arm connected to a carboxyl terminal of the polypeptide, and a lipophilic compound connected to the connecting arm; or the lipopeptide comprises a polypeptide having antiviral activity, and a lipophilic compound connected to a carboxyl terminal of the polypeptide. Further provided are derivatives of the lipopeptide, pharmaceutical compositions and uses of the lipopeptide.
(FR) L'invention concerne un lipopeptide capable d'inhiber le VIH. Le lipopeptide de l'invention comprend un polypeptide ayant une activité antivirale, un bras de liaison relié à une extrémité carboxyle du polypeptide, et un composé lipophile relié au bras de liaison ; ou le lipopeptide comprend un polypeptide ayant une activité antivirale, et un composé lipophile lié à une extrémité carboxyle du polypeptide. L'invention concerne en outre des dérivés du lipopeptide, des compositions pharmaceutiques et des utilisations du lipopeptide.
(ZH) 提供了抑制HIV的脂肽,该脂肽包括具有抗病毒活性的多肽,与多肽的羧基末端相连的连接臂,以及与连接臂相连的亲脂性化合物;或者该脂肽包括具有抗病毒活性的多肽,以及与多肽的羧基末端相连的亲脂性化合物。还提供了该脂肽的衍生物、药物组合物及其用途。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)