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1. (WO2018140974) PASSIVE ANTIBODY DEPENDENT CELL-MEDIATED ACTIVATION
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Pub. No.: WO/2018/140974 International Application No.: PCT/US2018/016035
Publication Date: 02.08.2018 International Filing Date: 30.01.2018
IPC:
A61K 38/00 (2006.01) ,A61K 38/08 (2006.01) ,C07K 14/00 (2006.01) ,C07K 17/00 (2006.01) ,C07K 2/00 (2006.01) ,C07K 4/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
04
Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
08
Peptides having 5 to 11 amino acids
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
17
Carrier-bound or immobilised peptides; Preparation thereof
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
2
Peptides of undefined number of amino acids; Derivatives thereof
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
4
Peptides having up to 20 amino acids in an undefined or only partially defined sequence; Derivatives thereof
Applicants:
CALIGIURI, Michael [US/US]; US
YU, Jianhua [CN/US]; US
DAI, Hongsheng [CN/US]; US
OHIO STATE INNOVATION FOUNDATION [US/US]; 1524 N. High St. Columbus, OH 43201, US
Inventors:
CALIGIURI, Michael; US
YU, Jianhua; US
DAI, Hongsheng; US
Agent:
FENDRICK, Sarah, E.; US
Priority Data:
62/452,11130.01.2017US
Title (EN) PASSIVE ANTIBODY DEPENDENT CELL-MEDIATED ACTIVATION
(FR) ACTIVATION À MÉDIATION CELLULAIRE DÉPENDANTE DES ANTICORPS PASSIFS
Abstract:
(EN) Disclosed herein are methods, reagents, and pharmaceutical compositions for modulating immune effector cell activation that does not requirean antigen-specific antibody. The IgG Fc region is shown herein to contain both a domain that binds an FcγR on immune effector cells and a non-overlapping region or domain that can bind Fc binding proteins on target cells, and that it is capable of bridging immune effector cells and target cells expressing Fc binding proteins without use of the antigen-binding region (Fab) of the antibody. Therefore, also disclosed are methods of enhancing or inhibiting passive ADCC in subjects.
(FR) L'invention concerne des procédés, des réactifs et des compositions pharmaceutiques pour moduler l'activation des cellules effectrices immunitaires qui ne nécessitent pas un anticorps spécifique de l'antigène. La région Fc des IgG selon la présente invention contient à la fois un domaine qui se lie à une région Fcγ sur des cellules effectrices immunitaires et une région ou un domaine non chevauchant qui peut lier des protéines de liaison Fc sur des cellules cibles, et elle est capable d'un pontage de cellules effectrices immunitaires et des cellules cibles exprimant des protéines de liaison Fc sans utiliser la région de liaison à l'antigène (Fab) de l'anticorps. Par conséquent, l'invention concerne également des procédés d'amélioration ou d'inhibition de la cytotoxicité à médiation cellulaire dépendante des anticorps (ADCC) passive chez des sujets.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)