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1. (WO2018140970) TUMOR SELECTIVE TATA-BOX AND CAAT-BOX MUTANTS
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Pub. No.: WO/2018/140970 International Application No.: PCT/US2018/016025
Publication Date: 02.08.2018 International Filing Date: 30.01.2018
IPC:
A61K 35/76 (2015.01) ,C12N 15/86 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35
Medicinal preparations containing material or reaction products thereof with undetermined constitution
66
Materials from micro-organisms
76
Viruses
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
63
Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79
Vectors or expression systems specially adapted for eukaryotic hosts
85
for animal cells
86
Viral vectors
Applicants:
EPICENTRX, INC. [US/US]; 4445 Eastgate Mall Suite 200 San Diego, CA 92121, US
Inventors:
REID, Tony, R.; US
ORONSKY, Bryan, T.; US
HEDJRAN, Farah; US
LARSON, Christopher; US
Agent:
DAVENPORT, Andrew, M.; US
BRODOWSKI, Michael; US
ARGENTIERI, Steven, R.; US
BUCHMAN, Joshua, J.; US
ASHRAF, Shovon; US
Priority Data:
62/452,07530.01.2017US
Title (EN) TUMOR SELECTIVE TATA-BOX AND CAAT-BOX MUTANTS
(FR) MUTANTS DE BOÎTE TATA ET DE BOÎTE CAAT SÉLECTIFS DE TUMEURS
Abstract:
(EN) The invention provides, e.g., a recombinant virus comprising (i) a modified TATA box-based promoter, and/or (ii) a modified CAAT box-based promoter operably linked to a gene, wherein the modified TATA box- based promoter and/or modified CAAT box-based promoter lacks a functional TATA box and/or CAAT box and permit selective expression of the gene in a hyperproliferative cell. The recombinant viruses can be used to treat cell proliferative diseases and disorders, including certain forms of cancer.
(FR) L'invention concerne, par exemple, un virus recombinant comprenant (i) un promoteur basé sur une boîte TATA modifiée et/ou (ii) un promoteur basé sur une boîte CAAT modifiée lié(s) de manière fonctionnelle à un gène, le promoteur basé sur une boîte TATA modifiée et/ou le promoteur basé sur une boîte CAAT modifiée étant dépourvu(s) de boîte TATA et/ou de boîte CAAT fonctionnelles et permettant une expression sélective du gène dans une cellule hyperproliférative. Les virus recombinants peuvent être utilisés pour traiter des maladies et des troubles de la prolifération cellulaire, y compris certaines formes de cancer.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)