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1. (WO2018140924) SYSTEMS AND METHODS FOR GENOME MAPPING
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/140924 International Application No.: PCT/US2018/015878
Publication Date: 02.08.2018 International Filing Date: 30.01.2018
IPC:
G01N 21/64 (2006.01) ,B01L 3/00 (2006.01) ,B82Y 15/00 (2011.01)
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21
Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible, or ultra-violet light
62
Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
63
optically excited
64
Fluorescence; Phosphorescence
B PERFORMING OPERATIONS; TRANSPORTING
01
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
L
CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
3
Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
B PERFORMING OPERATIONS; TRANSPORTING
82
NANO-TECHNOLOGY
Y
SPECIFIC USES OR APPLICATIONS OF NANO-STRUCTURES; MEASUREMENT OR ANALYSIS OF NANO-STRUCTURES; MANUFACTURE  OR TREATMENT OF NANO-STRUCTURES
15
Nano-technology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
Applicants: MASSACHUSETTS INSTITUTE OF TECHNOLOGY[US/US]; 77 Massachusetts Ave Cambridge, Massachusetts 02139, US
Inventors: MENG, Huaiyu; US
RAM, Rajeev J.; US
Agent: COLICE, Christopher Max; US
TEJA, Joseph, Jr.; US
BLINKA, Thomas A.; US
LUO, Yushan; US
Priority Data:
62/452,18130.01.2017US
Title (EN) SYSTEMS AND METHODS FOR GENOME MAPPING
(FR) SYSTÈMES ET PROCÉDÉS DE CARTOGRAPHIE DU GÉNOME
Abstract:
(EN) A system for molecular mapping includes a semiconductor substrate defining a reservoir to receive a sample of molecules and a nanofluidic channel in fluid communication with the reservoir. The system also includes a plurality of electrodes, in electrical communication with the nanofluidic channel, to electrophoretically trap the sample of molecules in the nanofluidic channel. At least one avalanche photodiode is fabricated in the semiconductor substrate and disposed within an optical near-field of the nanofluidic channel to detect fluorescence emission from at least one molecule in the sample of molecules.
(FR) L'invention concerne un système de cartographie moléculaire qui comprend un substrat semiconducteur définissant un réservoir pour recevoir un échantillon de molécules et un canal nanofluidique en communication fluidique avec le réservoir. Le système comprend également une pluralité d'électrodes, en communication électrique avec le canal nanofluidique, pour piéger par électrophorèse l'échantillon de molécules dans le canal nanofluidique. Au moins une photodiode à avalanche est fabriquée dans le substrat semiconducteur et disposée à l'intérieur d'un champ proche optique du canal nanofluidique pour détecter une émission de fluorescence provenant d'au moins une molécule dans l'échantillon de molécules.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)