Some content of this application is unavailable at the moment.
If this situation persist, please contact us atFeedback&Contact
1. (WO2018140863) FUSED IN SARCOMA (FUS) NUCLEAR TRANSLOCATION INHIBITORS FOR PREVENTING FIBROSIS
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/140863 International Application No.: PCT/US2018/015702
Publication Date: 02.08.2018 International Filing Date: 29.01.2018
IPC:
A61K 38/00 (2006.01) ,A61K 38/02 (2006.01) ,A61K 38/16 (2006.01) ,A61K 38/17 (2006.01)
[IPC code unknown for A61K 38][IPC code unknown for A61K 38/02][IPC code unknown for A61K 38/16][IPC code unknown for A61K 38/17]
Applicants:
VANDERBILT UNIVERSITY [US/US]; 2201 West End Avenue 305 Kirkland Hall Nashville, Tennessee 37240, US
THE UNITED STATES AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS [US/US]; 810 Vermont Ave, NW Washington, D.C., District of Columbia 20420, US
Inventors:
POZZI, Ambra A.; US
CHIUSA, Manuel; US
HAWIGER, Jack J.; US
ZIENKIEWICZ, Jozef; US
Agent:
LANIER, J. Gibson; US
HALL, Miles E.; US
Priority Data:
62/451,63627.01.2017US
Title (EN) FUSED IN SARCOMA (FUS) NUCLEAR TRANSLOCATION INHIBITORS FOR PREVENTING FIBROSIS
(FR) INHIBITEURS DE LA TRANSLOCATION NUCLÉAIRE DE LA PROTÉINE FUS PERMETTANT LA PRÉVENTION DE LA FIBROSE
Abstract:
(EN) Disclosed herein are compositions and methods for inhibiting collagen production mediated by the Fused in Sarcoma (FUS) ribonucleoprotein. As disclosed herein, the C terminal domain of FUS contains an uncommon nuclear localization sequence (NLS) motif called PY-NLS that binds the nuclear import receptor transportin. Phosphorylation of FUS leads to its association with transportin and nuclear translocation with consequent increased in collagen production. Therefore, disclosed herein is an isolated peptide having a transportin-binding moiety, which inhibits FUS from binding transportin, linked to a membrane translocating motif. These compositions and methods can be used to inhibit FUS-mediated collagen production, and treat fibrotic disease involving FUS-mediated collagen accumulation in kidneys and other organs displaying fibrotic diseases.
(FR) L'invention concerne des compositions et des méthodes pour inhiber la production de collagène médiée par la ribonucléoprotéine FUS. Selon l'invention, le domaine C-terminal de FUS contient un motif de séquence de localisation nucléaire (NLS) peu fréquent, appelé PY-NLS, qui se lie à un récepteur d'importation nucléaire, la transportine. La phosphorylation de FUS conduit à son association avec la transportine et à sa translocation nucléaire, ce qui entraîne une augmentation de la production du collagène. Par conséquent, l'invention concerne un peptide isolé possédant un élément de liaison à la transportine, qui empêche FUS de se lier à la transportine, lié à un motif de translocation membranaire. Ces compositions et méthodes peuvent être utilisées pour inhiber la production de collagène médiée par FUS, et pour traiter les maladies fibrotiques impliquant une accumulation de collagène médiée par FUS dans des reins et autres organes atteints de maladies fibrotiques.
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)