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1. (WO2018140858) THIOL ISOMERASES INHIBITORS AND USE THEREOF

Pub. No.:    WO/2018/140858    International Application No.:    PCT/US2018/015694
Publication Date: Fri Aug 03 01:59:59 CEST 2018 International Filing Date: Tue Jan 30 00:59:59 CET 2018
IPC: C07K 16/00
C07K 16/18
C07K 16/28
Applicants: WESTERN NEW ENGLAND UNIVERSITY
Inventors: KENNEDY, Daniel
GIBBINS, Jonathan
HOLBROOK, Lisa-Marie
Title: THIOL ISOMERASES INHIBITORS AND USE THEREOF
Abstract:
Disclosed herein is a method of administering to a patient in need thereof a therapeutically effective amount of an extracellular thiol isomerase inhibitor compound to treat or prevent a disease or condition influenced by the activity of one or more extracellular thiol isomerases (e.g. protein disulfide isomerase, ERp5, ERp57, ERp72 and thioredoxin). The disease or condition includes arterial thrombosis, venous thrombosis, a thrombotic disease, a cancer, an infectious disease, a viral disease, an immune disorder, inflammation, a neurologic disease, and a neurodegenerative disorder.