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1. (WO2018140826) CORE/SHELL STRUCTURE PLATFORM FOR IMMUNOTHERAPY

Pub. No.:    WO/2018/140826    International Application No.:    PCT/US2018/015601
Publication Date: Fri Aug 03 01:59:59 CEST 2018 International Filing Date: Sat Jan 27 00:59:59 CET 2018
IPC: A61K 39/39
A61K 9/127
A61K 9/51
A61P 35/00
Applicants: THE METHODIST HOSPITAL
Inventors: SHEN, Haifa
Title: CORE/SHELL STRUCTURE PLATFORM FOR IMMUNOTHERAPY
Abstract:
Disclosed are biocompatible core/shell compositions suitable for the delivery of populations of mRNA molecules to mammalian cells. The disclosed core-shell structured multicomponent compositions are optimized for the delivery of mRNAs encoding one or more cancer- or tumor-specific antigens to a population of antigen presenting cells, including, for example, human dendritic cells, macrophages and B cells. Also disclosed are methods for use of these compositions as therapeutic cancer vaccines.