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1. (WO2018140660) METHODS OF DETECTING AND DIAGNOSING TUBERCULOSIS USING ANTI-MTLDL ANTIBODIES
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Pub. No.: WO/2018/140660 International Application No.: PCT/US2018/015337
Publication Date: 02.08.2018 International Filing Date: 25.01.2018
IPC:
G01N 33/569 (2006.01) ,C07K 16/12 (2006.01) ,G01N 33/92 (2006.01)
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
569
for micro-organisms, e.g. protozoa, bacteria, viruses
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
12
against material from bacteria
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
92
involving lipids, e.g. cholesterol
Applicants:
THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK [US/US]; 35 State Street Albany, NY 12207, US
Inventors:
SAMPSON, Nicole; US
YANG, Xinxin; US
Agent:
SANDERS, Deirdre E.; US
BROOK, David, E.; US
SMITH, James, M.; US
WAKIMURA, Mary, Lou; US
CARROLL, Alice, O.; US
Priority Data:
62/450,84526.01.2017US
Title (EN) METHODS OF DETECTING AND DIAGNOSING TUBERCULOSIS USING ANTI-MTLDL ANTIBODIES
(FR) MÉTHODES DE DÉTECTION ET DE DIAGNOSTIC DE LA TUBERCULOSE AU MOYEN D'ANTICORPS ANTI-MTLDL
Abstract:
(EN) The present invention discloses a method for detecting level of Mycobacteria modified Low Density Lipoprotein (MtLDL) in a sample using antibodies or antibody fragments that bind specifically to MtLDL, compositions of such antibodies or antibody fragments and methods of using the same for detecting M. tuberculosis infection in a subject.
(FR) La présente invention concerne une méthode de détection du niveau de lipoprotéine basse densité modifiée par des mycobactéries (MtLDL) dans un échantillon à l'aide d'anticorps ou de fragments d'anticorps qui se lient spécifiquement à la MtLDL, des compositions de tels anticorps ou fragments d'anticorps et des méthodes d'utilisation de ceux-ci pour détecter une infection par M. tuberculosis chez un sujet.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)