WO2018140657 METHODS FOR BUILDING GENOMIC NETWORKS AND USES THEREOF

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Publication Number WO/2018/140657

Publication Date 02.08.2018

International Application No. PCT/US2018/015331

International Filing Date 25.01.2018

IPC

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CPC

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Applicants

WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH [US]/[US]
MASSACHUSETTS INSTITUTE OF TECHNOLOGY [US]/[US]

Inventors

KHURANA, Vikrram
CHUNG, Chee, Yeun
LINDQUIST, Susan
BERGER, Bonnie, A.
FRAENKEL, Ernest
PENG, Jian

Agents

WARREN, Lisa, M.

Priority Data

62/450,540

25.01.2017

Publication Language English (en)

Filing Language English (EN)

Designated States

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Title

(EN) METHODS FOR BUILDING GENOMIC NETWORKS AND USES THEREOF

(FR) PROCÉDÉS DE CONSTRUCTION DE RÉSEAUX GÉNOMIQUES ET LEURS UTILISATIONS

Abstract

(EN) Disclosed are methods, systems, cells and compositions directed to modeling a physiologic or pathologic process in an animal using a set of yeast genes analogous to a set of animal genes and augmenting the physiologic or pathologic process in the animal with predicted gene interactions based on the interactions between the set of yeast genes. Also disclosed are methods of screening for and using therapeutics for neurodegenerative proteinopathies.

(FR) L'invention concerne des procédés, des systèmes, des cellules et des compositions visant à modéliser un processus physiologique ou pathologique chez un animal consistant à utiliser un ensemble de gènes de levure analogues à un ensemble de gènes animaux et à accroître le processus physiologique ou pathologique chez l'animal avec des interactions géniques prédites sur la base des interactions entre l'ensemble de gènes de levure. L'invention concerne aussi des procédés de criblage et d'utilisation d'agents thérapeutiques pour des protéinopathies neurodégénératives.

C	CHEMISTRY; METALLURGY
12	BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N	MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15	Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor

C	CHEMISTRY; METALLURGY
12	BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N	MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15	Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09	Recombinant DNA-technology

C	CHEMISTRY; METALLURGY
12	BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N	MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15	Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09	Recombinant DNA-technology
87	Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation

C	CHEMISTRY; METALLURGY
12	BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N	MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15	Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09	Recombinant DNA-technology
87	Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
90	Stable introduction of foreign DNA into chromosome

C	CHEMISTRY; METALLURGY
12	BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N	MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15	Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor

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1. WO2018140657 - METHODS FOR BUILDING GENOMIC NETWORKS AND USES THEREOF

C	CHEMISTRY; METALLURGY
12	BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q	MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1	Measuring or testing processes involving enzymes, nucleic acids or microorganisms
02	involving viable microorganisms
025	for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics

G	PHYSICS
01	MEASURING; TESTING
N	INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2500	Screening for compounds of potential therapeutic value
10	involving cells

G	PHYSICS
16	INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
B	BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
25	ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression