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1. (WO2018140655) ELECTROCHEMICAL ANTIBODY-BASED BIOSENSOR
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Pub. No.: WO/2018/140655 International Application No.: PCT/US2018/015329
Publication Date: 02.08.2018 International Filing Date: 25.01.2018
IPC:
C07K 16/00 (2006.01) ,G01N 27/327 (2006.01) ,G01N 33/543 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
27
Investigating or analysing materials by the use of electric, electro-chemical, or magnetic means
26
by investigating electrochemical variables; by using electrolysis or electrophoresis
28
Electrolytic cell components
30
Electrodes, e.g. test electrodes; Half-cells
327
Biochemical electrodes
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
543
with an insoluble carrier for immobilising immunochemicals
Applicants:
NORTHEASTERN UNIVERSITY [US/US]; 360 Huntington Avenue Boston, MA 02115, US
Inventors:
GOLUCH, Edgar, D.; US
Agent:
HYMEL, Lin, J.; US
HJORTH, Beverly, E.; US
MAHANTA, Sanjeev, K.; US
Priority Data:
62/450,07325.01.2017US
Title (EN) ELECTROCHEMICAL ANTIBODY-BASED BIOSENSOR
(FR) BIOCAPTEUR ÉLECTROCHIMIQUE BASÉ SUR UN ANTICORPS
Abstract:
(EN) Methods and sensors using antibody-based electrochemical detection of analytes including small molecules make use of the specific recognition of analyte-bound antibody by the complement system protein C1q. The antibody is immobilized to an electrode to which a potential is applied and the C1q protein is linked to a redox-active molecule, such that binding of C1q to the analyte-bound antibody brings the redox-active molecule in contact with the electrode, whereupon the analyte is detected by an increase in current.
(FR) La présente invention concerne des méthodes et des capteurs utilisant une détection électrochimique basée sur un anticorps d'analytes comprenant de petites molécules, et qui font appel à la reconnaissance spécifique d'un anticorps lié à un analyte par la protéine du système complémentaire C1q. L'anticorps est immobilisé sur une électrode à laquelle un potentiel est appliqué et la protéine C1q est liée à une molécule à activité redox, de sorte que la liaison de C1q à l'anticorps lié à l'analyte amène la molécule à activité redox en contact avec l'électrode, après quoi l'analyte est détecté par élévation du courant.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)