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1. (WO2018140648) PYRROLOPYRIMIDINE ITK INHIBITORS FOR TREATING INFLAMMATION AND CANCER

Pub. No.:    WO/2018/140648    International Application No.:    PCT/US2018/015320
Publication Date: Fri Aug 03 01:59:59 CEST 2018 International Filing Date: Fri Jan 26 00:59:59 CET 2018
IPC: A61K 31/519
A61P 35/00
A61P 43/00
Applicants: ACLARIS THERAPEUTICS, INC.
Inventors: JACOBSEN, Eric Jon
BLINN, James Robert
SPRINGER, John Robert
HOCKERMAN, Susan Landis
ANDERSON, David Randolph
Title: PYRROLOPYRIMIDINE ITK INHIBITORS FOR TREATING INFLAMMATION AND CANCER
Abstract:
Disclosed herein are arylpyridinone compounds and compositions useful in the treatment of ITK mediated diseases, such as inflammation, having the structure of Formula (I) wherein R1, R2, and X are as defined in the detailed description. Methods of inhibition of ITK activity in a human or animal subject are also provided.