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1. (WO2018140648) PYRROLOPYRIMIDINE ITK INHIBITORS FOR TREATING INFLAMMATION AND CANCER
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/140648 International Application No.: PCT/US2018/015320
Publication Date: 02.08.2018 International Filing Date: 25.01.2018
IPC:
A61K 31/519 (2006.01) ,A61P 35/00 (2006.01) ,A61P 43/00 (2006.01)
Applicants: JACOBSEN, Eric Jon[US/US]; US
BLINN, James Robert[US/US]; US
SPRINGER, John Robert[US/US]; US
HOCKERMAN, Susan L.[US/US]; US
ANDERSON, David Randolph[US/US]; US
Inventors: JACOBSEN, Eric Jon; US
BLINN, James Robert; US
SPRINGER, John Robert; US
HOCKERMAN, Susan L.; US
ANDERSON, David Randolph; US
Agent: NEMLEKAR, Aparna; US
Priority Data:
62/450,45025.01.2017US
Title (EN) PYRROLOPYRIMIDINE ITK INHIBITORS FOR TREATING INFLAMMATION AND CANCER
(FR) INHIBITEURS D'ITK À BASE DE PYRROLOPYRIMIDINE POUR TRAITER L'INFLAMMATION ET LE CANCER
Abstract: front page image
(EN) Disclosed herein are arylpyridinone compounds and compositions useful in the treatment of ITK mediated diseases, such as inflammation, having the structure of Formula (I) wherein R1, R2, and X are as defined in the detailed description. Methods of inhibition of ITK activity in a human or animal subject are also provided.
(FR) L'invention concerne des composés et des compositions à base d'arylpyridinone qui sont utiles dans le traitement de maladies médiées par ITK, telles qu'une inflammation, présentant la structure de formule (I), dans laquelle R1, R2, et X sont tels que définis dans la description détaillée. L'invention concerne également des procédés d'inhibition de l'activité d'ITK chez un sujet humain ou animal.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)