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1. (WO2018140630) AUTOPHAGY INDUCERS FOR TREATMENT OF CNS CONDITIONS

Pub. No.:    WO/2018/140630    International Application No.:    PCT/US2018/015293
Publication Date: Fri Aug 03 01:59:59 CEST 2018 International Filing Date: Fri Jan 26 00:59:59 CET 2018
IPC: A61K 31/519
A61K 31/704
A61P 25/04
A61P 25/28
A61P 25/30
A61P 43/00
Applicants: NORTHWESTERN UNIVERSITY
THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
UNIVERSITY OF KANSAS
Inventors: HE, Congcong
HUANG, Sui
WANG, Chen
ROCCHI, Altea
MARUGAN, Juan Jose
FERRER, Marc
PATNAIK, Samarjit
CHEN, Yuchi
FRANKOWSKI, Kevin
SCHOENEN, Frank J.
Title: AUTOPHAGY INDUCERS FOR TREATMENT OF CNS CONDITIONS
Abstract:
The invention provides a compound of formula (I): wherein R1, R2, R3, and R4 are as defined herein, ginsenoside Rg2 of structure (II): or a combination thereof, for use in treating or preventing a condition responsive to the induction of autophagy in a brain of a mammal in need thereof.