Search International and National Patent Collections

1. (WO2018140599) BENZOTHIOPHENE AND BENZOTHIAZOLE COMPOUNDS AND METHODS OF USE THEREOF

Pub. No.:    WO/2018/140599    International Application No.:    PCT/US2018/015232
Publication Date: Fri Aug 03 01:59:59 CEST 2018 International Filing Date: Fri Jan 26 00:59:59 CET 2018
IPC: C07D 333/72
A61K 31/381
A61K 31/423
A61K 31/428
C07D 261/20
C07D 205/04
C07D 285/14
C07D 307/80
A61P 35/00
Applicants: ARAXES PHARMA LLC
Inventors: LI, Liansheng
FENG, Jun
LIU, Yuan
REN, Pingda
LIU, Yi
Title: BENZOTHIOPHENE AND BENZOTHIAZOLE COMPOUNDS AND METHODS OF USE THEREOF
Abstract:
Compounds having activity as inhibitors of G12C mutant KRAS protein are provided. The compounds have the following structure (I) or a pharmaceutically acceptable salt, stereoisomer or prodrug thereof, wherein B, Z, Ra, Rb, Rc, R1, L, L1 and E are as defined herein. Methods associated with preparation and use of such compounds, pharmaceutical compositions comprising such compounds and methods to modulate the activity of G12C mutant KRAS protein for treatment of disorders, such as cancer, are also provided.