Some content of this application is unavailable at the moment.
If this situation persist, please contact us atFeedback&Contact
1. (WO2018140586) USE OF APE/REF-1 REDOX SPECIFIC INHIBITORS FOR TREATING METASTATIC PROSTATE CANCER
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/140586 International Application No.: PCT/US2018/015205
Publication Date: 02.08.2018 International Filing Date: 25.01.2018
IPC:
A61K 31/122 (2006.01) ,A61K 31/192 (2006.01) ,A61P 35/04 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
12
Ketones
122
having the oxygen atom directly attached to a ring, e.g. quinones, vitamin K1, anthralin
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
185
Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
19
Carboxylic acids, e.g. valproic acid
192
having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
04
specific for metastasis
Applicants:
INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION [US/US]; 518 Indiana Ave. Indianapolis, IN 46202, US
Inventors:
KELLEY, Mark, R.; US
JERDE, Travis; US
FISHEL, Melissa, L.; US
Agent:
BOETTLER, Jeannie, M.; US
KAZMIERSKI, Steven T.; US
MEHTA, Samir R.; US
KIM, David S.; US
EIDSON, Bradley S.; US
CARLSON, Judith L.; US
CRONIN, James J.; US
SELLERS, Andrea F.; US
SLICER, Penny R.; US
TASSI, Elizabeth A.; US
TURNER, Colin W.; US
RIVARD, Ruth; US
Priority Data:
62/450,12525.01.2017US
Title (EN) USE OF APE/REF-1 REDOX SPECIFIC INHIBITORS FOR TREATING METASTATIC PROSTATE CANCER
(FR) UTILISATION D'INHIBITEURS SPÉCIFIQUES DE L'ACTIVITÉ REDOX D'APE/REF-1 POUR TRAITER LE CANCER MÉTASTATIQUE DE LA PROSTATE
Abstract:
(EN) Methods of using redox APEl/Ref-1 inhibitors to treat prostate cancer, and particularly, metastatic prostate cancer, are disclosed. Particularly, small molecule inhibitors of APEl/Ref-1 redox activity have been found to decrease cell proliferation and induce cell cycle arrest in metastatic prostate cancer cell lines. Further, these APEl/Ref-1 redox inhibitors can be used to reduce expression of survivin, which has been shown to be overexpressed in primary and metastatic tumors.
(FR) L'invention concerne des méthodes d'utilisation d'inhibiteurs de l'activité redox d'APE1/Ref-1 pour traiter le cancer de la prostate, et en particulier le cancer métastatique de la prostate. En particulier, il a été montré que des inhibiteurs de type petites molécules de l'activité redox d'APE1/Ref-1 diminuaient la prolifération cellulaire et induisaient un arrêt du cycle cellulaire dans des lignées cellulaires de cancer métastatique de la prostate. En outre, ces inhibiteurs de l'activité redox d'APE1/Ref-1 peuvent être utilisés pour faire diminuer l'expression de la survivine, dont il a été montré qu'elle est surexprimée dans des tumeurs primaires et métastatiques.
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)