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1. (WO2018140532) SYSTEMS AND METHODS FOR HEMATOPOIETIC CELL EXPANSION UTILIZING HYDROGELS
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Pub. No.: WO/2018/140532 International Application No.: PCT/US2018/015101
Publication Date: 02.08.2018 International Filing Date: 24.01.2018
IPC:
A61K 35/12 (2015.01) ,A61K 35/51 (2015.01) ,C12N 5/0789 (2010.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35
Medicinal preparations containing material or reaction products thereof with undetermined constitution
12
Materials from mammals or birds
[IPC code unknown for A61K 35/51]
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07
Animal cells or tissues
071
Vertebrate cells or tissues, e.g. human cells or tissues
078
Cells from blood or from the immune system
0789
Stem cells; Multipotent progenitor cells
Applicants:
FRED HUTCHINSON CANCER RESEARCH CENTER [US/US]; 1100 Fairview Avenue North Seattle, Washington 98109, US
Inventors:
DELANEY, Colleen; US
Agent:
WINGER, C. Rachal; US
WITTKOPP, Cristina J.; US
Priority Data:
62/449,99824.01.2017US
Title (EN) SYSTEMS AND METHODS FOR HEMATOPOIETIC CELL EXPANSION UTILIZING HYDROGELS
(FR) SYSTÈMES ET PROCÉDÉS D’EXPANSION DE CELLULES HÉMATOPOÏÉTIQUES AU MOYEN D’HYDROGELS
Abstract:
(EN) Systems and methods to expand hematopoietic stem cell (HSC) using zwitterionic hydrogels (ZTG) are described. Expansion using the disclosed systems and methods results in HSC populations with (i) an increased proportion of HSC versus partially or fully differentiated cells, (ii) proportionally lower cell surface expression levels of differentiation/maturation markers, (iii) reduced metabolic rates following expansion, and/or (iv) a greater proportion of quiescent cells following expansion, as compared to currently available clinical expansion methods.
(FR) La présente invention concerne des systèmes et des procédés d’expansion d’une cellule souche hématopoïétique (CDH) au moyen d’hydrogels zwitterioniques (ZTG). L’expansion au moyen des systèmes et des procédés de l’invention conduit à des populations de CSH avec (i) une proportion accrue de CSH par rapport à des cellules partiellement ou totalement différenciées, (ii) des taux d’expression de surface cellulaire proportionnellement inférieurs de marqueurs de différenciation/maturation, (iii) des taux métaboliques réduits après expansion, et/ou (iv) une proportion supérieure de cellules quiescentes après expansion, par rapport aux procédés d’expansion clinique actuellement disponibles.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)