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1. WO2018140507 - COMPOSITIONS AND RELATED METHODS FOR CONTROLLING VECTOR-BORNE DISEASES

Publication Number WO/2018/140507
Publication Date 02.08.2018
International Application No. PCT/US2018/015065
International Filing Date 24.01.2018
IPC
A61K 38/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61K 38/16 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
A61P 31/04 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
04Antibacterial agents
C07K 14/00 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
C07K 19/00 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
19Hybrid peptides
CPC
A61K 38/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
A61K 38/1703
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
1703from vertebrates
A61K 38/1729
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
1703from vertebrates
1709from mammals
1729Cationic antimicrobial peptides, e.g. defensins
A61K 38/1767
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
1767from invertebrates
A61P 31/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
04Antibacterial agents
C07K 14/43563
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
43504from invertebrates
43563from insects
Applicants
  • FLAGSHIP PIONEERING INNOVATIONS V, INC. [US]/[US]
Inventors
  • MARTINEZ, Ignacio
  • ARMEN, Zachary, Garo
  • CEZAR, Christine
  • MARTIN, Barry, Andrew
  • AVENDANO AMADO, Maier, Steve
Agents
  • ELBING, Karen, L.
  • DECAMP, James, D.
Priority Data
62/450,05724.01.2017US
62/583,91209.11.2017US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) COMPOSITIONS AND RELATED METHODS FOR CONTROLLING VECTOR-BORNE DISEASES
(FR) COMPOSITIONS ET PROCÉDÉS ASSOCIÉS POUR LUTTER CONTRE DES MALADIES VÉHICULÉES PAR UN VECTEUR
Abstract
(EN) Provided herein are methods and compositions useful for human health, e.g., for targeting one or more microorganisms resident in a host insect (e.g., arthropod, e.g., insect, e.g., pathogen vector), the modulation resulting in a decrease in the fitness of the host. The invention features a composition that includes a modulating agent (e.g., phage, peptide, small molecule, antibiotic, or combinations thereof) that can alter the host's microbiota in a manner that is detrimental to the host. By disrupting microbial levels, microbial activity, microbial metabolism, or microbial diversity, the modulating agent described herein may be used to decrease the fitness of a variety of insects that carry vector-borne pathogens that cause disease in humans.
(FR) La présente invention concerne des procédés et des compositions utiles pour la santé humaine, par exemple, pour cibler un ou plusieurs micro-organismes résidant chez un insecte hôte (par exemple, un arthropode, par exemple, un insecte, par exemple, un vecteur pathogène), la modulation conduisant à une diminution de la forme physique de l'hôte. L'invention concerne une composition qui comprend un agent de modulation (par exemple, un phage, un peptide, une petite molécule, un antibiotique ou des combinaisons de ceux-ci) qui peut altérer le microbiote de l'hôte d'une manière qui est préjudiciable à l'hôte. En perturbant les taux microbiens, l'activité microbienne, le métabolisme microbien ou la diversité microbienne, l'agent de modulation décrit dans la présente invention peut être utilisé pour diminuer la forme physique d'une variété d'insectes qui transportent des agents pathogènes véhiculés par un vecteur qui provoquent une maladie chez les êtres humains.
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