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1. (WO2018140504) COMPOSITIONS AND METHODS FOR BLOCKING SODIUM CHANNELS
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Pub. No.: WO/2018/140504 International Application No.: PCT/US2018/015059
Publication Date: 02.08.2018 International Filing Date: 24.01.2018
IPC:
C07D 233/54 (2006.01) ,A61K 31/4164 (2006.01) ,A61P 25/08 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
233
Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
54
having two double bonds between ring members or between ring members and non-ring members
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
4164
1,3-Diazoles
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
08
Antiepileptics; Anticonvulsants
Applicants:
PATEL, Manoj K. [US/US]; US
RIVARA, Mirko [IT/IT]; IT
Inventors:
PATEL, Manoj K.; US
RIVARA, Mirko; IT
Agent:
PERDOK, Monique M.; US
ARORA, Suneel, Reg. No. 42,267; US
BEEKMAN, Marvin L., Reg. No. 38,377; US
BIANCHI, Timothy E., Reg. No. 39,610; US
BLACK, David W., Reg. No. 42,331; US
GOULD, James R., Reg. No. 72,086; US
MCCRACKIN, Ann M., Reg. No. 42,858; US
SCHEER, Bradley W., Reg. No. 47,059; US
WOO, Justin N., Reg. No. 62,686; US
Priority Data:
62/449,81224.01.2017US
Title (EN) COMPOSITIONS AND METHODS FOR BLOCKING SODIUM CHANNELS
(FR) COMPOSITIONS ET PROCÉDÉS DE BLOCAGE DE CANAUX SODIQUES
Abstract:
(EN) The disclosure provides methods for treating a subject suffering from a disease associated with sodium channel activity. The method comprises administering to the subject a therapeutically effective amount of a compound according to Formula (II) or Formula (III) described in the specification, or a pharmaceutically acceptable salt, prodrug, tautomer, stereoisomer, hydrate, or solvate thereof.
(FR) L'invention concerne des procédés de traitement d'un sujet souffrant d'une maladie associée à l'activité du canal sodique. Le procédé comprend l'administration au sujet d'une quantité thérapeutiquement efficace d'un composé selon la formule II ou III décrite dans la description, ou d'un sel, promédicament, tautomère, stéréo-isomère, hydrate ou solvate pharmaceutiquement acceptable de celui-ci.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)