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1. WO2018140497 - APPARATUS AND METHODS FOR IN VITRO PRECLINICAL HUMAN TRIALS

Publication Number WO/2018/140497
Publication Date 02.08.2018
International Application No. PCT/US2018/015052
International Filing Date 24.01.2018
IPC
C12Q 1/00 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
G01N 33/50 2006.1
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
CPC
A01N 1/021
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES
1Preservation of bodies of humans or animals, or parts thereof
02Preservation of living parts
0205Chemical aspects
021Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
A01N 1/0247
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES
1Preservation of bodies of humans or animals, or parts thereof
02Preservation of living parts
0236Mechanical aspects
0242Apparatuses, i.e. devices used in the process of preservation of living parts, such as pumps, refrigeration devices or any other devices featuring moving parts and/or temperature controlling components
0247for perfusion, i.e. for circulating fluid through organs, blood vessels or other living parts
A01N 1/0278
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES
1Preservation of bodies of humans or animals, or parts thereof
02Preservation of living parts
0278Physical preservation processes
A01N 1/0284
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES
1Preservation of bodies of humans or animals, or parts thereof
02Preservation of living parts
0278Physical preservation processes
0284Temperature processes, i.e. using a designated change in temperature over time
B01L 2200/025
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
2200Solutions for specific problems relating to chemical or physical laboratory apparatus
02Adapting objects or devices to another
025Align devices or objects to ensure defined positions relative to each other
B01L 2200/10
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
2200Solutions for specific problems relating to chemical or physical laboratory apparatus
10Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
Applicants
  • EFIMOV, Igor, R. [US]/[US]
  • QIAO, Yun [CN]/[US]
  • KANG, Chaoyi [US]/[US]
  • LI, Zhenyu [CN]/[US]
  • DONG, Quan [CN]/[US]
  • LI, Baichen [CN]/[US]
Inventors
  • EFIMOV, Igor, R.
  • QIAO, Yun
  • KANG, Chaoyi
  • LI, Zhenyu
  • DONG, Quan
  • LI, Baichen
Agents
  • LONGSWORTH, Gaby, L.
  • BANOWIT, Donald, R.
  • BEZOS, Salvador, M.
  • BODENSTEIN, Matthew
  • CALVO, Paul, A.
  • CAMARCE, Christian
  • CIMBALA, Michele, A.
  • COLLER III, Richard, D.
  • CONKLIN, Kyle
  • CORNWELL, David, K., S.
  • COVERT, John, M.
  • DESAI, Nirav, N.
  • DURKIN, Tracy-Gene, G.
  • EISENBERG, Jason, D.
  • ELLISON, Eldora, L.
  • ESMOND, Robert, W.
  • FEATHERSTONE, Donald, J.
  • FRUEAUF, Jeremiah, B.
  • GAJEWSKI, Daniel
  • GASZNER, Miklos
  • GILLENTINE, Marsha, Rose
  • GOLDSTEIN, Jorge, A.
  • GORDON, Lori, A.
  • HELVEY, Jeffrey, T.
  • HICKS, Ross
  • HOLOUBEK, Michelle, K.
  • JACKMAN, Peter, A.
  • KIM, Ji-Eun
  • LAROCK, Adam
  • LEE, Michael, Q.
  • MILLONIG, Robert, C.
  • MUTSCHELKNAUS, Joseph
  • NANNENGA-COMBS, Bonnie
  • PICKARD, Byron, L.
  • POWERS, Trey
  • RAY, Michael, B.
  • RYGIEL, Mark, W.
  • SHEA JR., Timothy, J.
  • SOKOHL, Robert, E.
  • SPECHT, Michael, D.
  • STEFFE, Eric, K.
  • STERLING, Deborah, A.
  • STERNE, Robert, Greene
  • TUMINARO, Jonathan
  • VARUGHESE, Dennies
  • VIRA, Chandrika
  • WRIGHT, Jon, E.
  • YONAN, Daniel, E.
Priority Data
62/450,41225.01.2017US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) APPARATUS AND METHODS FOR IN VITRO PRECLINICAL HUMAN TRIALS
(FR) APPAREIL ET PROCÉDÉS POUR ESSAIS HUMAINS PRÉCLINIQUES IN VITRO
Abstract
(EN) Systems comprising a microfluidic device are provided for maintaining and analyzing tissue slices. Methods for maintaining tissue slices in a microfluidic device are further provided.
(FR) L'invention concerne des systèmes comprenant un dispositif microfluidique pour maintenir et analyser des coupes biologiques. L'invention concerne en outre des procédés de conservation de coupes biologiques dans un dispositif microfluidique.
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