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1. (WO2018140435) METHODS OF PREPARING CYTOTOXIC BENZODIAZEPINE DERIVATIVES
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Pub. No.: WO/2018/140435 International Application No.: PCT/US2018/014956
Publication Date: 02.08.2018 International Filing Date: 24.01.2018
IPC:
C07C 205/19 (2006.01) ,C07D 487/04 (2006.01) ,C07D 207/452 (2006.01) ,C07D 519/04 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
205
Compounds containing nitro groups bound to a carbon skeleton
13
the carbon skeleton being further substituted by hydroxy groups
19
having nitro groups bound to carbon atoms of six-membered aromatic rings and hydroxy groups bound to acyclic carbon atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
487
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
207
Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
02
with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
44
having three double bonds between ring members or between ring members and non-ring members
444
having two doubly-bound oxygen atoms directly attached in positions 2 and 5
448
with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. maleimide
452
with hydrocarbon radicals, substituted by hetero atoms, directly attached to the ring nitrogen atom
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
519
Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/ or C07D455/257
04
Dimeric indole alkaloids, e.g. vincaleucoblastine
Applicants:
IMMUNOGEN, INC. [US/US]; 830 Winter Street Waltham, MA 02451, US
Inventors:
GÉRARD, Baudouin; US
SILVA, Richard, A.; US
MILLER, Michael, Louis; US
SHIZUKA, Manami; US
Agent:
DAVIS, Steven, G.; US
BOWLES, Anita, M.; US
BLAZESKI, George; US
BELT, Erik, P.; US
BAI, Mei; US
Priority Data:
62/450,27025.01.2017US
Title (EN) METHODS OF PREPARING CYTOTOXIC BENZODIAZEPINE DERIVATIVES
(FR) PROCÉDÉS DE PRÉPARATION DE DÉRIVÉS DE BENZODIAZÉPINE CYTOTOXIQUES
Abstract:
(EN) The invention provides novel methods for preparing indolinobenzodiazepine dimer compounds and their synthetic precursors.
(FR) L'invention concerne de nouveaux procédés de préparation de composés dimères d'indolinobenzodiazépine et leur précurseurs synthétiques.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)