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1. (WO2018140412) NEOSTIGMINE COMBINATION AND COMPOSITIONS
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/140412 International Application No.: PCT/US2018/014901
Publication Date: 02.08.2018 International Filing Date: 23.01.2018
IPC:
A61P 21/04 (2006.01) ,A61K 31/4178 (2006.01) ,A61K 31/27 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
21
Drugs for disorders of the muscular or neuromuscular system
04
for myasthenia gravis
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
4164
1,3-Diazoles
4178
not condensed and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
21
Esters, e.g. nitroglycerine, selenocyanates
27
of carbamic or thiocarbamic acids, e.g. meprobamate, carbachol, neostigmine
Applicants: GT BIOPHARMA, INC.[US/US]; 1825 K Street, N.W. Suite 510 Washington, District of Columbia 20006-1236, US
Inventors: CLARENCE-SMITH, Kathleen E.; US
Agent: PHAN, TU A.; US
TOWNSLEY, ALAN C.; SUGHRUE MION, PLLC 2100 Pennsylvania Ave., N.W., Suite 800 Washington, District of Columbia 20037-3213, US
BIRD, JOHN; SUGHRUE MION, PLLC 2100 Pennsylvania Ave., N.W., Suite 800 Washington, District of Columbia 20037-3213, US
Priority Data:
62/449,69924.01.2017US
Title (EN) NEOSTIGMINE COMBINATION AND COMPOSITIONS
(FR) COMBINAISON DE NÉOSTIGMINE ET COMPOSITIONS
Abstract:
(EN) The present invention describes the use of a 5HT3-antagonist, in combination with neostigmine, to facilitate the treatment of a patient suffering from myasthenia gravis or other myasthenic syndromes by providing a therapeutically effective neostigmine bromide or methylsulfate daily dose that attenuates or even abrogates the dose-limiting gastrointestinal adverse effects of neostigmine.
(FR) La présente invention concerne l'utilisation d'un antagoniste de 5HT3, en combinaison avec la néostigmine, pour faciliter le traitement d'un patient souffrant de myasthénie grave ou d'autres syndromes myasthéniques en fournissant une dose quotidienne de bromure ou de méthylsulfate de néostigmine thérapeutiquement efficace qui atténue ou même supprime les effets secondaires gastro-intestinaux limitant les doses de néostigmine.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)