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1. (WO2018140270) TUNICAMYCIN RELATED COMPOUNDS WITH ANTI-BACTERIAL ACTIVITY

Pub. No.:    WO/2018/140270    International Application No.:    PCT/US2018/014041
Publication Date: Fri Aug 03 01:59:59 CEST 2018 International Filing Date: Thu Jan 18 00:59:59 CET 2018
IPC: C07H 19/06
A61K 31/43
A61K 31/545
A61K 31/7072
A61K 45/06
A61P 31/04
A01N 43/54
Applicants: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF AGRICULTURE
Inventors: PRICE, Neil P.
Title: TUNICAMYCIN RELATED COMPOUNDS WITH ANTI-BACTERIAL ACTIVITY
Abstract:
Tunicamycin related compounds having an acyl chain double bond reduced and/or having an acyl chain double bond and an uracil ring double bond reduced are described as well as methods of making these tunicamycin related compounds. These tunicamycin related compounds are not toxic to eukaryotic cells and can be used to kill Gram-positive bacteria, alone or in combination with other antibiotics. Use of these tunicamycin related compounds to kill Gram-positive bacteria, treat Gram-positive bacterial diseases, and disinfect objects or surfaces are described. In addition, naturally-occurring streptovirudin compounds are not toxic to eukaryotic cells and can be used to kill Gram-positive bacteria, alone or in combination with other antibiotics.