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1. (WO2018140242) STRUCTURAL BASIS FOR ANTIBODY CROSS-NEUTRALIZATION OF RESPIRATORY SYNCYTIAL VIRUS AND HUMAN METAPNEUMOVIRUS

Pub. No.:    WO/2018/140242    International Application No.:    PCT/US2018/013318
Publication Date: Fri Aug 03 01:59:59 CEST 2018 International Filing Date: Fri Jan 12 00:59:59 CET 2018
IPC: A61K 39/00
A61K 39/12
Applicants: VANDERBILT UNIVERSITY
Inventors: CROWE, James, E., Jr.
MOUSA, Jarrod
Title: STRUCTURAL BASIS FOR ANTIBODY CROSS-NEUTRALIZATION OF RESPIRATORY SYNCYTIAL VIRUS AND HUMAN METAPNEUMOVIRUS
Abstract:
The present disclosure is directed to antibodies binding to prefusion and postfusion forms of both human respiratory syncytial virus and human metapneumovirus F proteins, including neutralizing antibodies, and methods for use thereof.