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1. (WO2018140026) BISPECIFIC HER2 AND CD3 BINDING MOLECULES

Pub. No.:    WO/2018/140026    International Application No.:    PCT/US2017/015278
Publication Date: Fri Aug 03 01:59:59 CEST 2018 International Filing Date: Sat Jan 28 00:59:59 CET 2017
IPC: C07K 16/28
Applicants: MEMORIAL SLOAN KETTERING CANCER CENTER
Inventors: CHEUNG, Nai-Kong, V.
LOPEZ-ALBAITERO, Andres
XU, Hong
Title: BISPECIFIC HER2 AND CD3 BINDING MOLECULES
Abstract:
Provided herein are compositions, methods, and uses involving bispecific binding molecules that specifically bind to HER2, a receptor tyrosine kinase, and to CD3, a T cell receptor, and mediate T cell cytotoxicity for managing and treating disorders, such as cancer. Also provided herein are uses and methods for managing and treating HER2 -related cancers.