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1. (WO2018139502) FINDING AND TREATMENT OF INFLAMMATION AFTER BIRTH IN CHIMERIC ANIMAL

Pub. No.:    WO/2018/139502    International Application No.:    PCT/JP2018/002178
Publication Date: Fri Aug 03 01:59:59 CEST 2018 International Filing Date: Fri Jan 26 00:59:59 CET 2018
IPC: A61K 45/00
A61K 31/56
A61K 31/573
A61P 17/00
A61P 29/00
A61P 37/06
A61P 43/00
C12N 5/073
C12N 5/16
C12N 15/09
Applicants: THE UNIVERSITY OF TOKYO
国立大学法人 東京大学
Inventors: NAKAUCHI Hiromitsu
中内 啓光
YAMAGUCHI Tomoyuki
山口 智之
HAMANAKA Sanae
濱仲 早苗
SATO Hideyuki
佐藤 秀征
MASAKI Hideki
正木 英樹
MIZUNO Naoaki
水野 直彬
WATANABE Motoo
渡部 素生
Title: FINDING AND TREATMENT OF INFLAMMATION AFTER BIRTH IN CHIMERIC ANIMAL
Abstract:
The inventor of the present invention found that chimeric animals suffer from noticeable inflammation, though neither immune response nor inflammation in the fetal period of these animals has been reported hitherto. This is an unexpected finding since chimeric animals in the fetal period were exclusively analyzed in prior studies and thus it is deemed that immunotolerance has been theoretically established therein. The present invention provides a composition for suppressing immune response or inflammation in the fetal period of a born chimeric animal.