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1. (WO2018138744) COMPOSITION, DEVICE AND METHOD FOR CONFORMATIONAL INTRA-TISSUE BETA BRACHYTHERAPY
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Pub. No.: WO/2018/138744 International Application No.: PCT/IT2017/000292
Publication Date: 02.08.2018 International Filing Date: 22.12.2017
IPC:
A61K 9/00 (2006.01) ,A61K 47/38 (2006.01) ,A61P 35/00 (2006.01) ,A61K 51/06 (2006.01) ,A61B 6/00 (2006.01) ,A61N 5/10 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
30
Macromolecular compounds
36
Polysaccharides; Derivatives thereof
38
Cellulose; Derivatives thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
51
Preparations containing radioactive substances for use in therapy or testing in vivo
02
characterised by the carrier
04
Organic compounds
06
Macromolecular compounds
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
B
DIAGNOSIS; SURGERY; IDENTIFICATION
6
Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
N
ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
5
Radiation therapy
10
X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
Applicants:
DESANTIS, Maria [IT/IT]; IT
CIPRIANI, Cesidio [IT/IT]; IT
Inventors:
DESANTIS, Maria; IT
CIPRIANI, Cesidio; IT
Priority Data:
20201700000733024.01.2017IT
20201700000734424.01.2017IT
Title (EN) COMPOSITION, DEVICE AND METHOD FOR CONFORMATIONAL INTRA-TISSUE BETA BRACHYTHERAPY
(FR) COMPOSITION, DISPOSITIF ET PROCÉDÉ POUR CURIETHÉRAPIE BÊTA INTRA-TISSULAIRE CONFORMATIONNELLE
Abstract:
(EN) It is claimed the invention of a composition and a device to be used in medical therapy as a containment matrix in conformational intra-tissue beta brachytherapy. The composition is made so as to form a gel which can be injected intra-tissue without toxicity in the organism, holding in suspension during injection the particulate of a beta-emitting brachytherapy composition, and forming after injection a solid deposit that immobilizes the radiotherapeutic composition in the injection bolus, to prevent migration of the radioactive product into the surrounding tissues. The composition is injected with an apparatus dedicated to percutaneous intra-tissue injection comprising a 7-degree robotic apparatus, an automatic injection device under pressure, a needles system to provide the therapeutic composition application in the tissue to be treated with minimal trauma. An advanced software system is also included that allows interfacing between diagnostic imaging data, robotic arm movement scheduling, and composition dose distribution, in order to optimize the distribution of the radiotherapeutic doses of the composition into the tissue to be treated, according to a targeted individual therapeutic strategy. Additionally a method for using the invention for the application in human or animal medicine is claimed.
(FR) L'invention concerne une composition et un dispositif destinés à être utilisés dans le cadre d'un traitement médical pour former une matrice de confinement dans une curiethérapie bêta intra-tissulaire conformationnelle. La composition est fabriquée de manière à former un gel qui peut être injecté à l'intérieur d'un tissu sans toxicité pour l'organisme, maintenant en suspension pendant l'injection les particules d'une composition de curiethérapie à émission bêta, et formant, après l'injection, un dépôt solide qui immobilise la composition radiothérapeutique dans le bolus d'injection, pour empêcher la migration du produit radioactif dans les tissus environnants. La composition est injectée à l'aide d'un appareil dédié à l'injection intra-tissulaire percutanée comprenant un appareil robotique à 7 degrés de liberté, un dispositif d'injection automatique sous pression, un système d'aiguilles pour assurer l'administration de la composition thérapeutique dans le tissu à traiter de la façon la moins traumatisante possible. L'invention concerne également un système logiciel avancé qui permet l'interfaçage entre des données d'imagerie diagnostique, la planification des mouvements du bras robotique et la distribution de doses de composition, afin d'optimiser la répartition des doses radiothérapeutiques de composition dans le tissu à traiter, selon une stratégie thérapeutique individualisée cible. L'invention concerne en outre un procédé d'utilisation de l'invention pour application en médecine humaine ou animale.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)