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1. (WO2018138677) PROCESS FOR THE SYNTHESIS OF STIMULUS-RESPONSIVE MAGNETIC NANOPARTICLES
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Pub. No.: WO/2018/138677 International Application No.: PCT/IB2018/050477
Publication Date: 02.08.2018 International Filing Date: 26.01.2018
IPC:
A61K 41/00 (2006.01) ,A61P 35/00 (2006.01) ,A61K 47/69 (2017.01) ,B82Y 5/00 (2011.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
41
Medicinal preparations obtained by treating materials with wave energy or particle radiation
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
[IPC code unknown for A61K 47/69]
B PERFORMING OPERATIONS; TRANSPORTING
82
NANO-TECHNOLOGY
Y
SPECIFIC USES OR APPLICATIONS OF NANO-STRUCTURES; MEASUREMENT OR ANALYSIS OF NANO-STRUCTURES; MANUFACTURE  OR TREATMENT OF NANO-STRUCTURES
5
Nano-biotechnology or nano-medicine, e.g. protein engineering or drug delivery
Applicants:
FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA [IT/IT]; Via Morego 30 16163 Genova, IT
UNIVERSITA' DEGLI STUDI DI GENOVA [IT/IT]; Via Balbi 5 16126 Genova, IT
Inventors:
PELLEGRINO, Teresa; IT
MAI, Thanh Binh; VN
BARTHEL, Markus Joachim; DE
BALAKRISHNAN, Preethi Bala; IN
KAKWERE, Hamilton; ZW
CINGOLANI, Roberto; IT
Agent:
RAMBELLI, Paolo; IT
JACOBACCI, Guido; IT
QUINTERNO, Giuseppe; IT
GERBINO, Angelo; IT
FIORAVANTI, Corrado; IT
DEAMBROGI, Edgardo; IT
COMOGLIO, Elena; IT
RONDANO, Davide; IT
VANZINI, Christian; IT
Priority Data:
10201700000922127.01.2017IT
Title (EN) PROCESS FOR THE SYNTHESIS OF STIMULUS-RESPONSIVE MAGNETIC NANOPARTICLES
(FR) PROCÉDÉ DE SYNTHÈSE DE NANOPARTICULES MAGNÉTIQUES SENSIBLES À UN STIMULUS
Abstract:
(EN) Process for preparing magnetic nanoparticles coated with a thermo- or Ph-responsive polymer, characterized in that it comprises the radical polymerization of a monomer or co-monomers susceptible of forming a thermo-polymer or Ph-responsive copolymer in a solution including magnetic nanoparticles functionalized at their surface with a polymerization initiator of formula (I): wherein: R3 is hydrogen or hydroxyl, Hal is a halogen selected from bromine, chlorine and iodine, m is an integer from 1 to 10, preferably from 1 to 3, and R1 and R2, independently of one another, are selected from hydrogen, methyl and phenyl. The coated particles are useful, particularly as carriers of a drug in therapeutic treatments by hyperthermia and/or in situ release of the drug.
(FR) L'invention concerne un procédé de préparation de nanoparticules magnétiques revêtues d'un polymère thermosensible ou sensible au Ph, caractérisé en ce qu'il comprend la polymérisation radicalaire d'un monomère ou de co-monomères susceptibles de former un thermopolymère ou un copolymère sensible au Ph dans une solution comprenant des nanoparticules magnétiques fonctionnalisées à leur surface avec un initiateur de polymérisation de formule (I) : où : R3 est de l'hydrogène ou de l'hydroxyle, Hal est un halogène sélectionné parmi le brome, le chlore et l'iode, m est un nombre entier compris entre 1 et 10, de préférence entre 1 et 3, et R1 et R2, indépendamment l'un de l'autre, sont sélectionnés parmi l'hydrogène, le méthyle et le phényle. Les particules revêtues servent, en particulier, sous forme de supports d'un médicament, dans des traitements thérapeutiques par hyperthermie et/ou libération in situ du médicament.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: Italian (IT)