Some content of this application is unavailable at the moment.
If this situation persist, please contact us atFeedback&Contact
1. (WO2018138668) METHODS OF DIAGNOSING MALIGNANT DISEASES
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/138668 International Application No.: PCT/IB2018/050454
Publication Date: 02.08.2018 International Filing Date: 25.01.2018
IPC:
G01N 33/574 (2006.01) ,G01N 33/86 (2006.01)
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
574
for cancer
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
86
involving blood coagulating time
Applicants:
MOR RESEARCH APPLICATIONS LTD. [IL/IL]; 38 Habarzel St. 6971054 Tel Aviv, IL
RAMOT AT TEL AVIV UNIVERSITY LTD. [IL/IL]; P.O. Box 39296 6139201 Tel Aviv, IL
Inventors:
RABIZADEH, Esther; IL
CHERNY, Izchak; IL
INBAL, Aida; IL
Agent:
RICHTER, Allen; IL
SHIMONI, Gila; IL
Priority Data:
62/450,08225.01.2017US
Title (EN) METHODS OF DIAGNOSING MALIGNANT DISEASES
(FR) PROCÉDÉS DE DIAGNOSTIC DE MALADIES MALIGNES
Abstract:
(EN) A method for diagnosing a malignant proliferative disease or disorder in a subject, and/or for following up, monitoring or prognosticating the therapy of a malignant proliferative disease or disorder in a subject is disclosed. The method is based on measurement of platelet-mediated fibrinogen-like protein 2 (FGL2) activity in a sample essentially comprising platelets obtained from the subject. In accordance with the disclosed method, platelet-mediated FGL2 activity level higher than control is indicative of the presence of a malignant proliferative disease or disorder in a subject.
(FR) L'invention concerne un procédé de diagnostic d'une maladie ou un trouble prolifératif malin chez un sujet, et/ou de suivi, de surveillance ou de pronostic de la thérapie d'une maladie ou d'un trouble prolifératif malin chez un sujet. Le procédé est basé sur la mesure de l'activité de la protéine 2 de type fibrinogène médiée par les plaquettes (FGL2) dans un échantillon comprenant essentiellement des plaquettes obtenues du sujet. Selon le procédé de l'invention, un niveau d'activité FGL2 médié par les plaquettes supérieur au témoin indique la présence d'une maladie ou d'un trouble prolifératif malin chez un sujet.
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)