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1. (WO2018138591) CALICHEAMICIN DERIVATIVES AND ANTIBODY DRUG CONJUGATES THEREOF
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Pub. No.: WO/2018/138591 International Application No.: PCT/IB2018/050153
Publication Date: 02.08.2018 International Filing Date: 10.01.2018
IPC:
C07H 15/00 (2006.01) ,A61K 47/64 (2017.01)
[IPC code unknown for C07H 15][IPC code unknown for A61K 47/64]
Applicants:
PFIZER INC. [US/US]; 235 East 42nd Street New York, New York 10017, US
Inventors:
AHMAD, Omar Khaled; US
BROWN, Stephen Paul; US
DIRICO, Kenneth John; US
DUSHIN, Russell; US
FILZEN, Gary Frederick; US
PUTHENVEETIL, Sujiet; US
STROP, Pavel; US
SUBRAMANYAM, Chakrapani; US
TUMEY, Lawrence N.; US
Agent:
WALDRON, Roy F.; US
Priority Data:
62/449,83924.01.2017US
Title (EN) CALICHEAMICIN DERIVATIVES AND ANTIBODY DRUG CONJUGATES THEREOF
(FR) DÉRIVÉS DE CALICHÉAMICINE ET CONJUGUÉS ANTICORPS-MÉDICAMENTS DE CEUX-CI
Abstract:
(EN) The present invention is directed to novel calicheamicin derivatives useful as payloads in antibody-drug-conjugates (ADC's), and to payload-linker compounds and ADC compounds comprising the same; to pharmaceutical compositions comprising the same and to methods for using the same to treat pathological conditions such as cancer.
(FR) La présente invention concerne de nouveaux dérivés de calichéamicine utiles en tant que charges utiles dans des conjugués anticorps-médicament (ADC), des composés de liaison de charge utile et des composés ADC les comprenant ; des compositions pharmaceutiques les comprenant et des procédés d'utilisation de ceux-ci pour traiter des états pathologiques tels que le cancer.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)