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1. (WO2018138585) SCN9A ANTISENSE PAIN KILLER
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/138585 International Application No.: PCT/IB2018/000160
Publication Date: 02.08.2018 International Filing Date: 23.01.2018
IPC:
C07K 14/00 (2006.01) ,C12N 15/113 (2010.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
113
Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
Applicants: OLIPASS CORPORATION[KR/KR]; 20th Floor, Ace Dongbaek Tower 16 Beon-gil, 16-4 Dongbaek Jungang-ro Giheung-gu, Yongin-si Gyeonggi-do 17105, KR
Inventors: CHUNG, Shin; KR
JUNG, Daram; KR
CHO, Bongjun; KR
JANG, Kangwon; KR
JEON, Hyun Ju; KR
BAE, Jinyoung; KR
BAE, Taeyeon; KR
JEON, Yeasel; KR
LEE, Jun Yeon; KR
PARK, Sun Hwa; KR
AN, Dan Bi; KR
Priority Data:
62/449,73824.01.2017US
Title (EN) SCN9A ANTISENSE PAIN KILLER
(FR) ANTALGIQUE ANTI-SENS SCN9A
Abstract:
(EN) The current invention provides peptide nucleic acid derivatives targeting the 3' splice site of exon 4 in the human SCN9A pre-mRNA. The peptide nucleic acid derivatives potently induce SCN9A mRNA splice variant(s) lacking the SCN9A exon 4 in cells, and are useful to safely treat pains or conditions involving Nav1.7 activity.
(FR) La présente invention concerne des dérivés d'acide nucléique peptidique ciblant le site d'épissage 3' de l'exon 4 dans le pré-ARNm SCN9A humain. Les dérivés d'acide nucléique peptidique induisent puissamment dans les cellules, un ou des variants d'épissage d'ARNm SCN9A dépourvus de l'exon 4 SCN9A, et sont utiles pour traiter en toute sécurité des douleurs ou des états impliquant une activité de Nav1.7.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)