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1. (WO2018138578) COMPOSITIONS FOR THE TREATMENT OF HYPERTENSION
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Pub. No.: WO/2018/138578 International Application No.: PCT/IB2018/000083
Publication Date: 02.08.2018 International Filing Date: 23.01.2018
IPC:
A61K 31/549 (2006.01) ,A61K 31/41 (2006.01) ,A61K 31/4418 (2006.01) ,A61P 9/12 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
54
having six-membered rings with at least one nitrogen and at least one sulfur as the ring hetero atoms, e.g. sulthiame
549
having two or more nitrogen atoms in the same ring, e.g. hydrochlorothiazide
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
44
Non-condensed pyridines; Hydrogenated derivatives thereof
4418
having a carbocyclic ring directly attached to the heterocyclic ring, e.g. cyproheptadine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9
Drugs for disorders of the cardiovascular system
12
Antihypertensives
Applicants:
THE GEORGE INSTITUTE FOR GLOBAL HEALTH [AU/AU]; Level 5, 1 King Street Newton, Sydney, New South Wales, 2042, AU
Inventors:
RODGERS, Anthony; AU
MACMAHON, Stephen; US
Priority Data:
62/450,32425.01.2017US
Title (EN) COMPOSITIONS FOR THE TREATMENT OF HYPERTENSION
(FR) COMPOSITIONS POUR LE TRAITEMENT DE L'HYPERTENSION
Abstract:
(EN) Provided herein are pharmaceutical compositions that are useful for the treatment of hypertension comprising an angiotensin II receptor blocker, a diuretic, and a calcium channel blocker. These compositions are administered in a dose of 40-80% of the lowest hypertension therapeutic dose (LHTD) for each agent. The application is also directed to compositions comprising telmisartan, a thiazide-like diuretic and a calcium channel blocker, administered at a dose of 80-150% of the LHTD for each agent.
(FR) L'invention concerne des compositions pharmaceutiques qui sont utiles pour le traitement de l'hypertension, comprenant un bloqueur du récepteur de l'angiotensine II, un diurétique et un bloqueur des canaux calciques. Ces compositions sont administrées selon une dose de 40 à 80 % de la dose thérapeutique pour le traitement de l'hypertension la plus faible (LHTD) pour chaque agent. L'invention concerne également des compositions comprenant du telmisartan, un diurétique thiazidique et un bloqueur des canaux calciques, administrés selon une dose de 80 à 150 % de la LHTD pour chaque agent.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)