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1. (WO2018138468) BIOMARKERS OF TRAUMATIC BRAIN INJURY
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Pub. No.: WO/2018/138468 International Application No.: PCT/GB2017/053887
Publication Date: 02.08.2018 International Filing Date: 22.12.2017
IPC:
C12Q 1/6883 (2018.01)
[IPC code unknown for C12Q 1/6883]
Applicants:
THE UNIVERSITY OF BIRMINGHAM [GB/GB]; Edgbaston Birmingham West Midlands B15 2TT, GB
Inventors:
BELLI, Antonio; GB
DI PIETRO, Valentina; GB
Agent:
FINNIE, Isobel Lara; GB
Priority Data:
PCT/GB2017/05023130.01.2017GB
Title (EN) BIOMARKERS OF TRAUMATIC BRAIN INJURY
(FR) BIOMARQUEURS DE TRAUMATISME CRANIO-CÉRÉBRAL
Abstract:
(EN) Provided is a method of diagnosing and/or monitoring mild traumatic brain injury (mTBI) or concussion in a subject. The method comprises determining a level of at least one miRNA in a saliva sample from the subject. Also provided is a sensor element, a detection system, composition and a kit for diagnosing and/or monitoring TBI, and a method of determining an appropriate treatment for a subject with suspected mTBI or concussion.
(FR) L'invention concerne un procédé de diagnostic et/ou de surveillance d'un traumatisme cranio-cérébral (TCC) ou d'une commotion chez un sujet. Le procédé comprend la détermination d'un niveau d'au moins un miARN dans un échantillon de salive provenant du sujet. L'invention concerne également un élément de capteur, un système de détection, une composition et un nécessaire pour le diagnostic et/ou la surveillance d'un TCC et un procédé de détermination d'un traitement approprié pour un sujet soupçonné d'être atteint d'un TCC ou d'une commotion.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)