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1. (WO2018138362) N-{[2-(PIPERIDIN-1-YL)PHENYL](PHENYL)METHYL}-2-(3-OXO-3,4-DIHYDRO-2H-1,4-BENZOXA ZIN-7-YL)ACETAMIDE DERIVATIVES AND RELATED COMPOUNDS AS ROR-GAMMA MODULATORS FOR TREATING AUTOIMMUNE DISEASES

Pub. No.:    WO/2018/138362    International Application No.:    PCT/EP2018/052172
Publication Date: Fri Aug 03 01:59:59 CEST 2018 International Filing Date: Tue Jan 30 00:59:59 CET 2018
IPC: C07D 265/36
C07D 215/48
C07D 241/52
C07D 209/34
C07D 209/38
C07D 231/56
C07D 405/12
C07D 413/12
C07D 417/12
A61K 31/536
A61K 31/4725
A61K 31/498
A61K 31/454
A61K 31/425
A61P 37/00
A61P 37/06
A61P 37/08
A61P 31/00
A61P 19/02
A61P 11/06
Applicants: GENFIT
Inventors: DELHOMEL, Jean-François
PERSPICACE, Enrico
MAJD, Zouher
PARROCHE, Peggy
WALCZAK, Robert
Title: N-{[2-(PIPERIDIN-1-YL)PHENYL](PHENYL)METHYL}-2-(3-OXO-3,4-DIHYDRO-2H-1,4-BENZOXA ZIN-7-YL)ACETAMIDE DERIVATIVES AND RELATED COMPOUNDS AS ROR-GAMMA MODULATORS FOR TREATING AUTOIMMUNE DISEASES
Abstract:
The present invention provides e.g. N-{[2-(piperidin-1-yl)phenyl] (phenyl)methyl}-2-(3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl)acetamide derivatives and related compounds as ROR-gamma modulators for treating e.g. autoimmune diseases, autoimmune-related diseases, inflammatory diseases, metabolic diseases, fibrotic diseases or cholestatic diseases, such as e.g. arthitis and asthma.