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1. (WO2018138360) OXYGEN CARRYING BLOOD SUBSTITUTES AND THEIR USE AS DELIVERY VEHICLES

Pub. No.:    WO/2018/138360    International Application No.:    PCT/EP2018/052168
Publication Date: Fri Aug 03 01:59:59 CEST 2018 International Filing Date: Tue Jan 30 00:59:59 CET 2018
IPC: A61K 9/00
A61K 47/42
A61K 49/10
Applicants: CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CARLOS III (F.S.P.)
Inventors: IBÁÑEZ CABEZA, Borja
GARCÍA-RUIZ, Jose Manuel
AGÜERO RAMON-LLIN, Jaume
FERNÁNDEZ-JIMÉNEZ, Rodrigo
FUSTER CARULLA, Valentín
LARA-PEZZI, Enrique
BERNAL RODRÍQUEZ, Juan Antonio
GALÁN-ARRIOLA, Carlos
PUN GARCÍA, Andrés
CLINTON, Enda Joseph
Title: OXYGEN CARRYING BLOOD SUBSTITUTES AND THEIR USE AS DELIVERY VEHICLES
Abstract:
The present invention relates to the field of medicine and biotechnology. More specifically it relates to oxygen carrier compositions for the delivery of oxygen to tissues and organs (e.g., to the myocardium) under bloodless situations. It further relates to medical uses and methods of treatment comprising the administration thereof, for instance, as delivery vehicle for gene therapy purposes. In a particular embodiment, it relates to an oxygen carrier composition for use in a method for the in vivo diagnosis and/or treatment of a myocardial disease; wherein said method comprises the following consecutive steps: i. temporary occluding a coronary artery, and optionally, temporary occluding a coronary vein; ii. administering into the coronary artery downstream to the site of occlusion the oxygen carrier composition, wherein said oxygen carrier composition has been pre-oxygenated; and iii. administering into the coronary artery downstream to the site of occlusion a diagnostic, prophylactic and/or therapeutic agent and the oxygen carrier composition; wherein the oxygen carrier composition in ii) is substantially free of the diagnostic, prophylactic and/or therapeutic agent administered in iii); and wherein in step iii) the agent and the oxygen carrier composition are administered simultaneously.