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1. (WO2018138358) PERK AND IRE-1A INHIBITORS AGAINST NEURODEVELOPMENTAL DISORDERS
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Pub. No.: WO/2018/138358 International Application No.: PCT/EP2018/052165
Publication Date: 02.08.2018 International Filing Date: 29.01.2018
IPC:
A61K 31/165 (2006.01) ,A61K 31/4706 (2006.01) ,A61K 31/519 (2006.01) ,A61P 25/00 (2006.01)
[IPC code unknown for A61K 31/165][IPC code unknown for A61K 31/4706][IPC code unknown for A61K 31/519][IPC code unknown for A61P 25]
Applicants:
UNIVERSITÉ DE LIÈGE [BE/BE]; Place du Vingt Août 7 4000 Liège, BE
Inventors:
NGUYEN, Laurent; BE
CREPPE, Catherine; BE
ALFANO, Christian; BE
GLADWYN-NG, Ivan; BE
CORDON BARRIS, Lluis; BE
Agent:
LC PATENTS; Kempische Steenweg 542A 3500 Hasselt, BE
Priority Data:
17153834.130.01.2017EP
17195823.410.10.2017EP
Title (EN) PERK AND IRE-1A INHIBITORS AGAINST NEURODEVELOPMENTAL DISORDERS
(FR) INHIBITEURS DE PERK ET D'IRE-1A CONTRE DES TROUBLES NEURODÉVELOPPEMENTAUX
Abstract:
(EN) The present invention relates to UPR pathway inhibitors, in particular PERK and IRE-1 A inhibitors for use in the prevention or treatment of neurodevelopmental disorders, such as microcephaly caused by ZIKV.
(FR) La présente invention concerne des inhibiteurs de la voie UPR, en particulier des inhibiteurs de PERK et d'IRE-1A destinés à être utilisés dans la prévention ou le traitement de troubles neurodéveloppementaux, tels que la microcéphalie provoqué par le ZIKV.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)