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1. (WO2018138085) ALKOXY BIS-HETEROARYL DERIVATIVES AS MODULATORS OF PROTEIN AGGREGATION

Pub. No.:    WO/2018/138085    International Application No.:    PCT/EP2018/051579
Publication Date: Fri Aug 03 01:59:59 CEST 2018 International Filing Date: Wed Jan 24 00:59:59 CET 2018
IPC: C07D 417/12
C07D 417/14
A61K 31/496
A61P 25/28
Applicants: UCB BIOPHARMA SPRL
Inventors: HALL, Adrian
MACCOSS, Malcolm
Title: ALKOXY BIS-HETEROARYL DERIVATIVES AS MODULATORS OF PROTEIN AGGREGATION
Abstract:
The present invention relates to certain bis-heteroaryl compounds, pharmaceutical compositions containing them, and methods of using them, including methods for preventing, reversing, slowing, or inhibiting protein aggregation, and methods of treating diseases that are associated with protein aggregation, including neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease, Lewy body disease, Parkinson's disease with dementia, fronto-temporal dementia, Huntington's Disease, amyotrophic lateral sclerosis, and multiple system atrophy, and cancer including melanoma.