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1. (WO2018138028) BENZYLAMINOPYRAZINYLCYCLOPROPANECARBOXYLIC ACIDS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF

Pub. No.:    WO/2018/138028    International Application No.:    PCT/EP2018/051385
Publication Date: Fri Aug 03 01:59:59 CEST 2018 International Filing Date: Tue Jan 23 00:59:59 CET 2018
IPC: C07D 241/20
C07D 403/12
C07D 405/12
C07D 409/12
C07D 413/12
C07D 417/12
A61P 3/04
A61P 9/04
A61P 9/12
A61P 3/10
A61K 31/497
Applicants: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
Inventors: ECKHARDT, Matthias
WAGNER, Holger
Title: BENZYLAMINOPYRAZINYLCYCLOPROPANECARBOXYLIC ACIDS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF
Abstract:
The present invention relates to compounds of general formula (I), wherein the groups R, R1, R2, R3, m and n are defined as in claim 1, which have valuable pharmacological properties, in particular bind to the GPR40 receptor and modulate its activity. The compounds are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular diabetes type 2.