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1. (WO2018137683) LANOSTEROL PRODRUG COMPOUND AND PREPARATION METHOD THEREFOR AND USE THEREOF

Pub. No.:    WO/2018/137683    International Application No.:    PCT/CN2018/074120
Publication Date: Fri Aug 03 01:59:59 CEST 2018 International Filing Date: Fri Jan 26 00:59:59 CET 2018
IPC: C07J 9/00
A61K 31/575
A61K 9/08
A61P 27/12
Applicants: ZHONGSHAN OPHTHALMIC CENTER, SUN YAT-SEN UNIVERSITY
中山大学中山眼科中心
Inventors: LIU, Yizhi
刘奕志
WANG, Yandong
王延东
LI, Xiaolin
李小林
LUO, Zhi
罗志
SHEN, Liang
沈良
HOU, Lijuan
候丽娟
WEN, Xinxin
文欣欣
HE, Haiying
贺海鹰
LI, Jian
黎健
CHEN, Shuhui
陈曙辉
Title: LANOSTEROL PRODRUG COMPOUND AND PREPARATION METHOD THEREFOR AND USE THEREOF
Abstract:
Disclosed are a lanosterol prodrug compound, a pharmaceutically acceptable salt and an isomer thereof, and a pharmaceutical composition comprising the lanosterol prodrug compound and the use thereof in the preparation of a drug for treating cataracts. The lanosterol prodrug compound has a better permeability than lanosterol.