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|1. (WO2018137629) RISPERIDONE SUSTAINED RELEASE COMPOSITION AND PREPARATION METHOD THEREFOR|
|Applicants:||AC PHARMACEUTICALS CO., LTD.
|Title:||RISPERIDONE SUSTAINED RELEASE COMPOSITION AND PREPARATION METHOD THEREFOR|
Disclosed are a sustained release composition and a preparation method therefor. The non-solvent preparation raw materials comprise risperidone, a sparingly water-soluble polymer and a release regulator. The release regulator comprises an organic lipophilic substance. The preparation method comprises the following steps: (1) dissolving the non-solvent preparation raw materials in an organic solvent to form an internal oil phase; (2) dissolving a surfactant in an aqueous medium to form an external aqueous phase; and (3) adding the internal oil phase obtained in step (1) to the external aqueous phase to prepare an emulsion, and then hardening microparticles in the solution by means of solvent evaporation or solvent extraction, collecting the microparticles, and washing and drying same.