Some content of this application is unavailable at the moment.
If this situation persist, please contact us atFeedback&Contact
1. (WO2018137629) RISPERIDONE SUSTAINED RELEASE COMPOSITION AND PREPARATION METHOD THEREFOR
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/137629 International Application No.: PCT/CN2018/073899
Publication Date: 02.08.2018 International Filing Date: 24.01.2018
IPC:
A61K 9/52 (2006.01) ,A61K 31/519 (2006.01) ,A61K 47/12 (2006.01) ,A61K 47/44 (2017.01) ,A61K 47/34 (2017.01) ,A61P 25/18 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
48
Preparations in capsules, e.g. of gelatin, of chocolate
52
Sustained or differential release type
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519
ortho- or peri-condensed with heterocyclic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
06
Organic compounds
08
containing oxygen
12
Carboxylic acids; Salts or anhydrides thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
44
Oils, fats or waxes according to more than one of groups A61K47/02-A61K47/42109
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
30
Macromolecular compounds
34
Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
18
Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
Applicants:
广州帝奇医药技术有限公司 AC PHARMACEUTICALS CO., LTD. [CN/CN]; 中国广东省广州市 国际生物岛螺旋三路8号第3层301、302、303单元 Suite 301-303, Building 8 3rd Luoxuan Road Guangzhou International Bio-Island Guangzhou, Guangdong 510300, CN
Inventors:
刘锋 LIU, Feng; CN
赖树挺 LAI, Shuting; CN
郑阳 ZHENG, Yang; CN
曹付春 CAO, Fuchun; CN
连远发 LIAN, Yuanfa; CN
Agent:
广州华进联合专利商标代理有限公司 ADVANCE CHINA IP LAW OFFICE; 中国广东省广州市天河区珠江东路6号4501房 (部位:自编01-03和08-12单元)(仅限办公用途) Room 4501, No. 6 Zhujiang East Road, Tianhe District, Guangzhou Guangdong 510623, CN
Priority Data:
201710052701.324.01.2017CN
Title (EN) RISPERIDONE SUSTAINED RELEASE COMPOSITION AND PREPARATION METHOD THEREFOR
(FR) COMPOSITION À LIBÉRATION PROLONGÉE DE RISPÉRIDONE, ET PROCÉDÉ DE PRÉPARATION DE CETTE DERNIÈRE
(ZH) 一种利培酮缓释组合物及其制备方法
Abstract:
(EN) Disclosed are a sustained release composition and a preparation method therefor. The non-solvent preparation raw materials comprise risperidone, a sparingly water-soluble polymer and a release regulator. The release regulator comprises an organic lipophilic substance. The preparation method comprises the following steps: (1) dissolving the non-solvent preparation raw materials in an organic solvent to form an internal oil phase; (2) dissolving a surfactant in an aqueous medium to form an external aqueous phase; and (3) adding the internal oil phase obtained in step (1) to the external aqueous phase to prepare an emulsion, and then hardening microparticles in the solution by means of solvent evaporation or solvent extraction, collecting the microparticles, and washing and drying same.
(FR) La présente invention concerne une composition à libération prolongée et son procédé de préparation. Les matières premières de préparation sans solvant comprennent de la rispéridone, un polymère peu soluble dans l'eau, et un régulateur de libération. Le régulateur de libération comprend une substance lipophile organique. Le procédé de préparation comprend les étapes suivantes : (1) dissoudre les matières premières de préparation sans solvant dans un solvant organique pour former une phase huileuse interne ; (2) dissoudre un tensioactif dans un milieu aqueux pour former une phase aqueuse externe ; et (3) ajouter la phase huileuse interne obtenue à l'étape (1) à la phase aqueuse externe pour préparer une émulsion, puis faire durcir des microparticules dans la solution par évaporation du solvant ou par extraction par solvant, collecter les microparticules, et laver et sécher ces dernières.
(ZH) 一种缓释组合物及其制备方法,非溶剂型制备原料包含利培酮、水难溶性聚合物和释放调节剂,所述释放调节剂包含有机亲油性物质,制备方法包括以下步骤:(1)将非溶剂型制备原料溶于有机溶剂中,形成内油相;(2)将表面活性剂溶于水性介质中,形成外水相;(3)将步骤(1)得到的内油相加入到外水相中,制成乳液,然后通过溶剂蒸发或溶剂提取使溶液中的微粒硬化,收集微粒,洗涤并干燥。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)