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1. (WO2018137629) RISPERIDONE SUSTAINED RELEASE COMPOSITION AND PREPARATION METHOD THEREFOR

Pub. No.:    WO/2018/137629    International Application No.:    PCT/CN2018/073899
Publication Date: Fri Aug 03 01:59:59 CEST 2018 International Filing Date: Thu Jan 25 00:59:59 CET 2018
IPC: A61K 9/52
A61K 31/519
A61K 47/12
A61K 47/44
A61K 47/34
A61P 25/18
Applicants: AC PHARMACEUTICALS CO., LTD.
广州帝奇医药技术有限公司
Inventors: LIU, Feng
刘锋
LAI, Shuting
赖树挺
ZHENG, Yang
郑阳
CAO, Fuchun
曹付春
LIAN, Yuanfa
连远发
Title: RISPERIDONE SUSTAINED RELEASE COMPOSITION AND PREPARATION METHOD THEREFOR
Abstract:
Disclosed are a sustained release composition and a preparation method therefor. The non-solvent preparation raw materials comprise risperidone, a sparingly water-soluble polymer and a release regulator. The release regulator comprises an organic lipophilic substance. The preparation method comprises the following steps: (1) dissolving the non-solvent preparation raw materials in an organic solvent to form an internal oil phase; (2) dissolving a surfactant in an aqueous medium to form an external aqueous phase; and (3) adding the internal oil phase obtained in step (1) to the external aqueous phase to prepare an emulsion, and then hardening microparticles in the solution by means of solvent evaporation or solvent extraction, collecting the microparticles, and washing and drying same.