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1. WO2018137614 - HETEROAROTHIADIAZIDE-2,2-DIOXIDE DERIVATIVE, AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF IN MEDICAMENT

Publication Number WO/2018/137614
Publication Date 02.08.2018
International Application No. PCT/CN2018/073815
International Filing Date 23.01.2018
IPC
C07D 513/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
513Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/, C07D477/232
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
A61K 31/542 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
54having six-membered rings with at least one nitrogen and at least one sulfur as the ring hetero atoms, e.g. sulthiame
542ortho- or peri-condensed with heterocyclic ring systems
A61P 31/14 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
A61P 35/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
CPC
A61K 31/542
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
54having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
542ortho- or peri-condensed with heterocyclic ring systems
A61P 31/14
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07D 513/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
513Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
Y02P 20/55
YSECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
20Technologies relating to chemical industry
50Improvements relating to the production of bulk chemicals
55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Applicants
  • 江苏恒瑞医药股份有限公司 JIANGSU HENGRUI MEDICINE CO., LTD. [CN]/[CN]
  • 上海恒瑞医药有限公司 SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD. [CN]/[CN]
Inventors
  • 张国宝 ZHANG, Guobao
  • 陈一千 CHEN, Yiqian
  • 贺峰 HE, Feng
  • 陶维康 TAO, Weikang
Agents
  • 北京戈程知识产权代理有限公司 GE CHENG & CO., LTD.
Priority Data
201710059379.724.01.2017CN
Publication Language Chinese (ZH)
Filing Language Chinese (ZH)
Designated States
Title
(EN) HETEROAROTHIADIAZIDE-2,2-DIOXIDE DERIVATIVE, AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF IN MEDICAMENT
(FR) DÉRIVÉ D'HÉTÉROAROTHIADIAZIDE-2,2-DIOXYDE, SON PROCÉDÉ DE PRÉPARATION ET APPLICATION DE CELUI-CI DANS UN MÉDICAMENT
(ZH) 杂芳基并噻二嗪-2,2-二氧化物类衍生物、其制备方法及其在医药上的应用
Abstract
(EN)
Disclosed are a heteroarothiadiazide-2,2-dioxide derivative, and a preparation method therefor and an application thereof in medicament. Specifically, disclosed are a novel heteroarothiadiazide-2,2-dioxide derivative represented by formula (I), a preparation method therefor, a pharmaceutical composition containing the derivative, and a use as a therapeutic agent, especially as a TLR7 agonist. Each substituent group in formula (I) is defined as that in the description.
(FR)
L'invention concerne un dérivé d'hétéroarothiadiazide-2,2-dioxyde, son procédé de préparation et une application de celui-ci dans un médicament. L'invention concerne particulièrement, un nouveau dérivé d'hétéroarothiadiazide-2,2-dioxyde représenté par la formule (I), son procédé de préparation, une composition pharmaceutique contenant le dérivé, et une utilisation en tant qu'agent thérapeutique, en particulier en tant qu'agoniste TLR7. Selon la présente invention, chaque groupe substituant dans la formule (I) est tel que défini dans la description.
(ZH)
本发明公开了杂芳基并噻二嗪-2,2-二氧化物类衍生物、其制备方法及其在医药上的应用。具体而言,本发明公开了一种通式(I)所示的新的杂芳基并噻二嗪-2,2-二氧化物类衍生物、其制备方法及含有该衍生物的药物组合物以及其作为治疗剂,特别是作为TLR7激动剂的用途,其中通式(I)的各取代基与说明书中的定义相同。
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